A4GALT

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A4GALT
Identifiers
Aliases A4GALT, A14GALT, A4GALT1, Gb3S, P(k), P1, P1PK, PK, alpha 1,4-galactosyltransferase, alpha 1,4-galactosyltransferase (P blood group)
External IDs MGI: 3512453 HomoloGene: 9690 GeneCards: A4GALT
EC number 2.4.1.228
Gene location (Human)
Chromosome 22 (human)
Chr. Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for A4GALT
Genomic location for A4GALT
Band 22q13.2 Start 42,692,112 bp[1]
End 42,721,298 bp[1]
RNA expression pattern
PBB GE A4GALT 219488 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017436
NM_001318038

NM_001004150
NM_001170954

RefSeq (protein)

NP_001304967
NP_059132

NP_001004150
NP_001164425

Location (UCSC) Chr 22: 42.69 – 42.72 Mb Chr 15: 83.23 – 83.25 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.[5][6]

The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128274 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047878 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU (Sep 2000). "Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals". J Biol Chem. 275 (33): 25315–21. doi:10.1074/jbc.M002630200. PMID 10854428. 
  6. ^ a b "Entrez Gene: A4GALT alpha 1,4-galactosyltransferase (globotriaosylceramide synthase)". 

Further reading[edit]

External links[edit]