ABI gene family member 3

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ABI3
Identifiers
Aliases ABI3, NESH, SSH3BP3, ABI family member 3
External IDs MGI: 1913860 HomoloGene: 9505 GeneCards: ABI3
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for ABI3
Genomic location for ABI3
Band 17q21.32 Start 49,210,227 bp[1]
End 49,223,225 bp[1]
RNA expression pattern
PBB GE ABI3 gnf1h00229 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135186
NM_016428

NM_001163464
NM_025659

RefSeq (protein)

NP_001128658
NP_057512

NP_001156936
NP_079935

Location (UCSC) Chr 17: 49.21 – 49.22 Mb Chr 17: 95.83 – 95.84 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ABI gene family member 3 (ABI3) also known as new molecule including SH3 (Nesh) is a protein that in humans is encoded by the ABI3 gene.[5][6][7]

Function[edit]

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinases.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108798 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018381 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Miyazaki K, Matsuda S, Ichigotani Y, Takenouchi Y, Hayashi K, Fukuda Y, Nimura Y, Hamaguchi M (Nov 2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein". Biochim Biophys Acta. 1493 (1–2): 237–41. doi:10.1016/s0167-4781(00)00158-5. PMID 10978530. 
  6. ^ Ichigotani Y, Yokozaki S, Fukuda Y, Hamaguchi M, Matsuda S (Apr 2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res. 62 (8): 2215–9. PMID 11956071. 
  7. ^ a b "Entrez Gene: ABI3 ABI gene family, member 3". 

External links[edit]

Further reading[edit]