ABI gene family member 3

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ABI family, member 3
Symbols ABI3 ; NESH; SSH3BP3
External IDs OMIM606363 MGI1913860 HomoloGene9505 GeneCards: ABI3 Gene
RNA expression pattern
PBB GE ABI3 gnf1h00229 at tn.png
More reference expression data
Species Human Mouse
Entrez 51225 66610
Ensembl ENSG00000108798 ENSMUSG00000018381
UniProt Q9P2A4 Q8BYZ1
RefSeq (mRNA) NM_001135186 NM_001163464
RefSeq (protein) NP_001128658 NP_001156936
Location (UCSC) Chr 17:
49.21 – 49.22 Mb
Chr 11:
95.83 – 95.84 Mb
PubMed search [1] [2]

ABI gene family member 3 (ABI3) also known as new molecule including SH3 (Nesh) is a protein that in humans is encoded by the ABI3 gene.[1][2][3]


This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinases.[3]


  1. ^ Miyazaki K, Matsuda S, Ichigotani Y, Takenouchi Y, Hayashi K, Fukuda Y, Nimura Y, Hamaguchi M (Nov 2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein". Biochim Biophys Acta 1493 (1-2): 237–41. doi:10.1016/s0167-4781(00)00158-5. PMID 10978530. 
  2. ^ Ichigotani Y, Yokozaki S, Fukuda Y, Hamaguchi M, Matsuda S (Apr 2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res 62 (8): 2215–9. PMID 11956071. 
  3. ^ a b "Entrez Gene: ABI3 ABI gene family, member 3". 

Further reading[edit]