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Protein ADH1B PDB 1deh.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases ADH1B, ADH2, HEL-S-117, alcohol dehydrogenase 1B (class I), beta polypeptide
External IDs OMIM: 103720 HomoloGene: 133563 GeneCards: ADH1B
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ADH1B
Genomic location for ADH1B
Band 4q23 Start 99,304,964 bp[1]
End 99,352,760 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 4: 99.3 – 99.35 Mb n/a
PubMed search [2] n/a
View/Edit Human

Alcohol dehydrogenase 1B is an enzyme that in humans is encoded by the ADH1B gene.[3]

The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.[4]

The human gene is located on chromosome 4 in 4q22.

Previously ADH1B was called ADH2. There are more genes in the family of alcohol and aldehyde dehydrogenase genes. These genes are now referred to as ADH1A, ADH1C, and ADH4, ADH5, ADH6 and ADH7.[5]


A single nucleotide polymorphism (SNP) in ADH1B is rs1229984, that changes arginine to histidine at residue 47.[6] The 'typical' variant of this has been referred to as ADH2(1) or ADH2*1 while the 'atypical' has been referred to as, e.g., ADH2(2), ADH2*2, ADH1B*47his, or ADH1B arg47-to-his. This SNP may be related to alcohol consumption with the atypical genotype having reduced risk of alcoholism.[7]

Another SNP is Arg369Cys.[8]

Role in pathology[edit]

A marked decrease of ADH1B mRNA was detected in corneal fibroblasts taken from persons suffering from keratoconus.[9]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196616 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Smith M (Mar 1986). "Genetics of human alcohol and aldehyde dehydrogenases". Adv Hum Genet. 15: 249–90. doi:10.1007/978-1-4615-8356-1_5. PMID 3006456. 
  4. ^ "Entrez Gene: ADH1B alcohol dehydrogenase IB (class I), beta polypeptide". 
  5. ^ Sandra Porter (2008-08-21). "A gene by many other names and thoughts on teaching bioinformatics". ScienceBlogs. Archived from the original on 2009-02-15. Retrieved 2008-09-03. 
  6. ^ Y. Matsuo; R. Yokoyama & S. Yokoyama (August 1989). "The genes for human alcohol dehydrogenases beta 1 and beta 2 differ by only one nucleotide". European Journal of Biochemistry. 183 (2): 317–20. doi:10.1111/j.1432-1033.1989.tb14931.x. PMID 2547609. 
  7. ^ T. Muramatsu; Z. C. Wang; Y. R. Fang; K. B. Hu; H. Yan; K. Yamada; S. Higuchi; S. Harada & H. Kono (August 1995). "Alcohol and aldehyde dehydrogenase genotypes and drinking behavior of Chinese living in Shanghai". Human Genetics. 96 (2): 151–154. doi:10.1007/BF00207371. PMID 7635462. 
  8. ^ J. C. Burnell; L. G. Carr; F. E. Dwulet; H. J. Edenberg; T. K. Li & W. F. Bosron (August 1987). "The human beta 3 alcohol dehydrogenase subunit differs from beta 1 by a Cys for Arg-369 substitution which decreases NAD(H) binding". Biochemical and Biophysical Research Communications. 146 (3): 1127–33. PMID 3619918. 
  9. ^ Mootha VV, Kanoff JM, Shankardas J, Dimitrijevich S (2009). "Marked reduction of alcohol dehydrogenase in keratoconus corneal fibroblasts". Mol. Vis. 15: 706–12. PMC 2666775Freely accessible. PMID 19365573. 

Further reading[edit]

External links[edit]