enzymology, a phosphoribosylaminoimidazolecarboxamide formyltransferase ( EC 18.104.22.168), also known by the shorter name AICAR transformylase, is an enzyme that catalyzes the chemical reaction
AICAR tetrahydrofolate + FAICAR
Thus, the two
substrates of this enzyme are 10-formyltetrahydrofolate and AICAR, whereas its two products are tetrahydrofolate and FAICAR.
This enzyme participates in
purine metabolism and one carbon pool by folate.
Nomenclature [ edit ]
This enzyme belongs to the family of
transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 10-formyltetrahydrofolate:5-phosphoribosyl-5-amino-4-imidazole-carb oxamide N-formyltransferase. Other names in common use include:
5-amino-4-imidazolecarboxamide ribonucleotide transformylase,
5-amino-4-imidazolecarboxamide ribotide transformylase,
aminoimidazolecarboxamide ribonucleotide transformylase, and
Structural studies [ edit ]
As of late 2007, 11
structures have been solved for this class of enzymes, with PDB accession codes 1G8M, 1M9N, 1OZ0, 1P4R, 1PKX, 1PL0, 1THZ, 2B1G, 2B1I, 2IU0, and 2IU3.
References [ edit ]
HARTMAN SC, BUCHANAN JM (1959). "Biosynthesis of the purines. XXVI. The identification of the formyl donors of the transformylation reactions". J. Biol. Chem. 234 (7): 1812–6. PMID 13672969.