Phosphoribosylaminoimidazolecarboxamide formyltransferase

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phosphoribosylaminoimidazolecarboxamide formyltransferase
EC no.
CAS no.9032-03-5
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a phosphoribosylaminoimidazolecarboxamide formyltransferase (EC, also known by the shorter name AICAR transformylase, is an enzyme that catalyzes the chemical reaction

10-formyltetrahydrofolate + AICAR tetrahydrofolate + FAICAR

Thus, the two substrates of this enzyme are 10-formyltetrahydrofolate and AICAR, whereas its two products are tetrahydrofolate and FAICAR.

This enzyme participates in purine metabolism and one carbon pool by folate.


This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 10-formyltetrahydrofolate:5-phosphoribosyl-5-amino-4-imidazole-carb oxamide N-formyltransferase. Other names in common use include:

  • 10-formyltetrahydrofolate:5-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase
  • 5-amino-1-ribosyl-4-imidazolecarboxamide 5-phosphate,
  • 5-amino-4-imidazolecarboxamide ribonucleotide transformylase,
  • 5-amino-4-imidazolecarboxamide ribotide transformylase,
  • 5-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase,
  • AICAR formyltransferase,
  • AICAR transformylase,
  • aminoimidazolecarboxamide ribonucleotide transformylase, and
  • transformylase,
  • bifunctional purine biosynthesis protein PURH,
  • ATIC.

Structural studies[edit]

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 1G8M, 1M9N, 1OZ0, 1P4R, 1PKX, 1PL0, 1THZ, 2B1G, 2B1I, 2IU0, and 2IU3.


  • HARTMAN SC, BUCHANAN JM (1959). "Biosynthesis of the purines. XXVI. The identification of the formyl donors of the transformylation reactions". J. Biol. Chem. 234 (7): 1812–6. PMID 13672969.