Abarelix

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Abarelix
Abarelix.svg
Clinical data
Trade namesPlenaxis
AHFS/Drugs.comMonograph
Pregnancy
category
  • US: X (Contraindicated)
Routes of
administration
Intramuscular injection
Drug classGnRH analogue; GnRH antagonist; Antigonadotropin
ATC code
Pharmacokinetic data
Protein binding96–99%
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC72H95ClN14O14
Molar mass1416.06 g/mol g·mol−1
3D model (JSmol)
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Abarelix, sold under the brand name Plenaxis, is an injectable gonadotropin-releasing hormone antagonist (GnRH antagonist) which is marketed in Germany and the Netherlands. It is primarily used in oncology to reduce the amount of testosterone made in patients with advanced symptomatic prostate cancer for which no other treatment options are available.[2][3]

It was originally marketed by Praecis Pharmaceuticals as Plenaxis,[2] and is now marketed by Speciality European Pharma in Germany[4] after receiving a marketing authorization in 2005. The drug was introduced in the United States in 2003, but was discontinued in this country in May 2005 due to poor sales and a higher-than-expected incidence of severe allergic reactions.[5] It remains marketed in Germany and the Netherlands however.[6]

See also[edit]

References[edit]

  1. ^ "Abarelix". PubChem. 2017-07-29.
  2. ^ a b Drugs.com: Abarelix
  3. ^ Boccon-Gibod, L.; Van Der Meulen, E.; Persson, B. -E. (2011). "An update on the use of gonadotropin-releasing hormone antagonists in prostate cancer" (Full text). Therapeutic Advances in Urology. 3 (3): 127–140. doi:10.1177/1756287211414457. PMC 3159401. PMID 21904569.
  4. ^ Pharmazeutische Zeitung online: Abarelix (in German)
  5. ^ Boris Minev (13 January 2011). Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures. Springer Science & Business Media. pp. 182–. ISBN 978-90-481-9704-0.
  6. ^ https://www.drugs.com/international/abarelix.html