Dopamine antagonist

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Dopamine receptor antagonist
Dopaminergic blockers
Drug class
Use Schizophrenia, bipolar disorder, nausea and vomiting, etc.
Biological target Dopamine receptors
ATC code N05A
External links
MeSH D012559

A dopamine antagonist is a drug which blocks dopamine receptors by receptor antagonism. There are five known types of dopamine receptors in the human body; they are found in the brain, peripheral nervous system, blood vessels, gastrointestinal tract[1] and the kidney.

Uses and examples[edit]

Clozapine, a second generation antipsychotic

Dopamine receptor antagonists are used for some diseases such as schizophrenia, bipolar disorder, nausea and vomiting. It can also control the symptoms of hypersexuality and increased orgasmic activity.

Antidopaminergics such as haloperidol can be an antidote for poisoning with cocaine, amphetamines and dopamine agonists such as bromocriptine and/or ropinirole.

Side effects[edit]

They may include one or more of the following and last indefinitely even after cessation of the dopamine antagonist, especially after long-term or high-dosage use:


Examples of Dopamine antagonists include:[2]

See also[edit]


External links[edit]