dopamine antagonist (antidopaminergic) is a type of drug which blocks dopamine receptors by receptor antagonism. Most antipsychotics are dopamine antagonists, and as such they have found use in treating schizophrenia, bipolar disorder, and stimulant psychosis. Several other dopamine antagonists are antiemetics used in the treatment of nausea and vomiting.
Uses and examples [ edit ]
Clozapine, a second generation antipsychotic
Dopamine receptor antagonists are used for some diseases such as
schizophrenia, bipolar disorder, nausea and vomiting. It can also control the symptoms of hypersexuality and increased orgasmic activity.
Antidopaminergics such as
haloperidol can be an antidote for poisoning with cocaine, amphetamines and dopamine agonists such as bromocriptine and/or ropinirole.
Agents such as
atypical antipsychotics (coupled with serotonin antagonist effects): paliperidone, clozapine, risperidone, olanzapine, quetiapine, and ziprasidone Used as
antiemetics: metoclopramide, droperidol, domperidone Used as
tricyclic antidepressants: amoxapine, clomipramine, trimipramine
Choline can antagonize dopamine directly or interfere with receptor function
Melatonin suppresses dopamine activity as part of normal [1 ] circadian rhythm functions, although pathological imbalances have been implicated in Parkinson's disease [2 ]
Side effects [ edit ]
They may include one or more of the following and last indefinitely even after cessation of the
dopamine antagonist, especially after long-term or high-dosage use:
Examples [ edit ]
Examples of Dopamine antagonists include:
See also [ edit ]
References [ edit ]
^ Zisapel, N (2001). "Melatonin-dopamine interactions: from basic neurochemistry to a clinical setting". Cellular and Molecular Neurobiology 21 (6): 605–16. PMID 12043836.
^ Willis, GL (2008). "Parkinson's disease as a neuroendocrine disorder of circadian function: dopamine-melatonin imbalance and the visual system in the genesis and progression of the degenerative process". Reviews in the Neurosciences 19 (4–5): 245–316. PMID 19145986.
^ MeSH list of agents 82018492
External links [ edit ]