Aldehyde oxidase 1

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AOX1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases AOX1, AO, AOH1, aldehyde oxidase 1
External IDs MGI: 88035 HomoloGene: 68165 GeneCards: AOX1
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for AOX1
Genomic location for AOX1
Band 2q33.1 Start 200,585,868 bp[1]
End 200,677,064 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001159

NM_009676

RefSeq (protein)

NP_001150

NP_033806

Location (UCSC) Chr 2: 200.59 – 200.68 Mb Chr 1: 58.03 – 58.11 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene.[5][6]

Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide.[5]

Clinical significance[edit]

Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138356 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063558 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: aldehyde oxidase 1". 
  6. ^ a b Berger R, Mezey E, Clancy KP, Harta G, Wright RM, Repine JE, Brown RH, Brownstein M, Patterson D (March 1995). "Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis". Somat. Cell Mol. Genet. 21 (2): 121–31. doi:10.1007/BF02255787. PMID 7570184. 

External links[edit]

Further reading[edit]