Azim Surani
Azim Surani | |
|---|---|
| Born | 1945 (age 78–79) |
| Alma mater | Plymouth University (BSc) University of Strathclyde (MSc) University of Cambridge (PhD) |
| Awards | Gabor Medal (2001) Royal Medal (2010) Mendel Lectures (2010) Gairdner Foundation International Award (2018)[1] |
| Scientific career | |
| Institutions | University of Cambridge |
| Thesis | Modulation of Implanting Rat Blastocysts to Macromolecular Secretions of the Uterus (1975) |
| Doctoral advisor | Robert Edwards |
| Doctoral students | Kat Arney[2] |
| Other notable students | Anne Ferguson-Smith (postdoc)[3] |
| Website | www |
Azim Surani CBE FRS FMedSci[1] (born 1945 in Kisumu, Kenya) is a developmental biologist who has been Marshall–Walton Professor at the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge since 1992, and Director of Germline and Epigenomics Research since 2013.[4][5]
Education
Azim was educated at the Plymouth University (BSc),[when?] the University of Strathclyde (MSc)[6] and the University of Cambridge (PhD) where his research was supervised by the Nobel laureate Robert Edwards.[6][7][1]
Career and research
Surani discovered mammalian genomic imprinting in 1984, and subsequently examined its mechanism and the functions of imprinted genes.[1] He later established the genetic basis for germ cell specification, using a single-cell analysis in mice.[1] This genetic network also initiates the unique resetting of the germline epigenome, including comprehensive erasure of DNA methylation towards re-establishing full genomic potency.[1] Epigenetic modifications and re-establishments of imprints then generate functional differences between parental genomes whilst aberrant imprints contribute to human disease.[1]
Surani's research is identifying key regulators of human germ line development and epigenome reprogramming, revealing differences between humans and mice attributable to their divergent pluripotent states and early postimplantation development.[1] He is also investigating transposable elements, host defence mechanisms, noncoding RNAs, and the potential for transgenerational epigenetic inheritance in mammals.[1]
Awards and honours
Surani has received several awards for his work including the Royal Medal (2010), the Gabor Medal (2001) and the Mendel Lectures (2010).
References
- ^ a b c d e f g h i Anon (1990). "Professor Azim Surani". royalsociety.org. London: Royal Society. Archived from the original on 2015-11-17. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --Royal Society Terms, conditions and policies at the Wayback Machine (archived 2016-11-11)
- ^ Arney, Katharine Luisa (2002). Epigenetic modification in the mouse zygote and regulation of imprinted genes (PhD thesis). University of Cambridge. OCLC 894595629.
- ^ Ferguson-Smith, A. C.; Cattanach, B. M.; Barton, S. C.; Beechey, C. V.; Surani, M. A. (1991). "Embryological and molecular investigations of parental imprinting on mouse chromosome 7". Nature. 351 (6328): 667–670. doi:10.1038/351667a0. ISSN 0028-0836. PMID 2052093.
- ^ Azim Surani publications indexed by the Scopus bibliographic database. (subscription required)
- ^ "Azim Surani — The Gurdon Institute". Gurdon.cam.ac.uk. Retrieved 29 August 2017.
- ^ a b McFarlane, Alan (2009). "Azim Surani interviewed by Alan Macfarlane". alanmacfarlane.com. Archived from the original on 2016-03-06.
- ^ Surani, M. A. H. (1975). Modulation of Implanting Rat Blastocysts to Macromolecular Secretions of the Uterus. ethos.bl.uk (PhD thesis). University of Cambridge. OCLC 500574338.
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