Beatrice received a good education at her father's court in Naples.
She was engaged in 1474 and married Matthias in Hungary 22 December 1476: she was crowned Queen of Hungary in Székesfehérvár.
The marriage secured an alliance between Hungary and Naples: In 1480, when an Ottoman fleet seized Otranto in the Kingdom of Naples, at the earnest solicitation of the pope he sent the Hungarian general, Blaise Magyar, to recover the fortress, which surrendered to him on 10 May 1481. Again in 1488, Matthias took Ancona under his protection for a while, occupying it with a Hungarian garrison. Beatrice exerted some influence in the policy of Hungary. She also had a cultural importance by introducing the Italian renaissance into the court of Hungary, an interest she shared with Matthias: she encouraged his work with the Bibliotheca Corviniana, built the palace Visegrád as a residence for the court, and created an academy. She wished to participate in policy: in 1477, she accompanied Matthias during the invasion of Austria, and in 1479, she was present during the peace treaty between Matthias and Vladislaus II.
In 1479, their relationship became tense when Matthias awarded his illegitimate son John (János) Corvinus with a fief and invited John's mother, Barbara Edelpöck, to court. Matthias died before Beatrice ever conceded that his son János should be the rightful heir. Upon his death in 1490, Beatrice managed to keep a power position by the support of the Hungarian nobility and continue as queen of Hungary by marriage to the next monarch. After the death of Matthias Corvinus, she wrote a letter to Simon Keglevich; she addressed this letter to king Simon Keglevich, then only the commander of Matthias Corvinus. She offered him to become as a mother to his children. He declined this offer; he delivered this letter to the parliament, and he became the ambassador of the parliament to the king. She presided as a royal representative at the parliament where the next king was elected, with the Hungarian crown placed at her side. It is believed she could not control Janos and was claimed illegitimate by her second husband but these claims all cannot be verified nor can they be completely ignored.
Vladislaus II of Bohemia and Hungary wrote in the same year 1490 many letters with the same text to many of the Hungarian nobility. He wrote that Beatrice had written to him, that Matthias Corvinus and Beatrice had decided that Stephen Zápolya, the father of John Zápolya, should become the next duke of Austria after Matthias Corvinus.
Beatrice married her second husband, Vladislaus II of Bohemia and Hungary, in 1491. Beatrice had great support by the Hungarian nobility, and the nobility had demanded of Vladislav that he marry her. This marriage was yet again childless. Formally, the marriage was questioned, as her spouse was not granted a divorce from his first wife by the pope. Her husband claimed that he did not regard the marriage as legal, and that he had been forced to marry her against his will, and in 1493, a commission was issued to investigate. In 1500, the pope declared the marriage to be illegal, and Beatrice was forced to pay the costs of the trial. Beatrice returned to Naples, where she arrived in 1501, and in 1502 Vladislaus could marry Anne of Foix-Candale. Beatrice died in Naples.
