Brenner tumour
| Brenner tumour | |
|---|---|
| Specialty | Gynecologic oncology  |
Brenner tumors are an uncommon subtype of the surface epithelial-stromal tumor group of ovarian neoplasms. The majority are benign, but some can be malignant.[1]
They are most frequently found incidentally on pelvic examination or at laparotomy.[2] Brenner tumours very rarely can occur in other locations, including the testes.[3]
Presentation
On gross pathological examination, they are solid, sharply circumscribed and pale yellow-tan in colour. 90% are unilateral (arising in one ovary, the other is unaffected). The tumours can vary in size from less than 1 centimetre (0.39 in) to 30 centimetres (12 in). Borderline and malignant Brenner tumours are possible but each are rare.
Diagnosis
Histologically, there are nests of transitional epithelial (urothelial) cells with longitudinal nuclear grooves (coffee bean nuclei) lying in abundant fibrous stroma.
Similar conditions
Transitional cell carcinoma is an even rarer entity, in which neoplastic transitional epithelial cells similar to transitional cell carcinoma of the bladder are seen in the ovary, without the characteristic stromal/epithelial pattern of a Brenner tumour.
Eponym
It is named for Fritz Brenner (1877–1969), a German surgeon who characterized it in 1907.[4] The term "Brenner tumor" was first used by Robert Meyer, in 1932.[5]
Additional images
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Micrograph of a Walthard cell nest, the entity Brenner tumours are thought to arise from. H&E stain.
References
- ^ Marwah N, Mathur SK, Marwah S, Singh S, Karwasra RK, Arora B (2005). "Malignant Brenner tumour--a case report". Indian J Pathol Microbiol. 48 (2): 251–2. PMID 16758686.
- ^ Green GE, Mortele KJ, Glickman JN, Benson CB (2006). "Brenner tumors of the ovary: sonographic and computed tomographic imaging features". J Ultrasound Med. 25 (10): 1245–51, quiz 1252–4. PMID 16998096.
- ^ Caccamo D, Socias M, Truchet C (1991). "Malignant Brenner tumor of the testis and epididymis". Arch. Pathol. Lab. Med. 115 (5): 524–7. PMID 2021324.
- ^ Lamping JD, Blythe JG (1977). "Bilateral Brenner tumors: a case report and review of the literature". Hum. Pathol. 8 (5): 583–5. doi:10.1016/S0046-8177(77)80117-2. PMID 903146.
- ^ Philipp, Elliot Elias; O'Dowd, Michael J. (2000). The history of obstetrics and gynaecology. Carnforth, Lancs: Parthenon. p. 586. ISBN 1-85070-040-0.
External links
- "Brenner tumour". Medcyclopaedia. GE. Archived from the original on 2012-02-05.
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