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Centromere protein B also known as major centromere autoantigen B is an autoantigen protein of the cell nucleus. In humans, centromere protein B is encoded by the CENPB gene.[5][6][7]
Function
Centromere protein B is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
^Sugimoto K, Yata H, Himeno M (July 1993). "Mapping of the human CENP-B gene to chromosome 20 and the CENP-C gene to chromosome 12 by a rapid cycle DNA amplification procedure". Genomics. 17 (1): 240–2. doi:10.1006/geno.1993.1312. PMID8406460.{{cite journal}}: CS1 maint: multiple names: authors list (link)
^Briasoulis E, Kamposioras K, Tzovaras V, Pafitanis G, Kostoula A, Mavridis A, Pavlidis N (May 2008). "CENP-B specific anti-centromere autoantibodies heralding small-cell lung cancer. A case study and review of the literature". Lung Cancer. 60 (2): 302–6. doi:10.1016/j.lungcan.2007.09.014. PMID17980453.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Further reading
Saxena A; Wong LH; Kalitsis P; et al. (2002). "Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc". Hum. Mol. Genet. 11 (19): 2319–29. doi:10.1093/hmg/11.19.2319. PMID12217960. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Orthaus S; Biskup C; Hoffmann B; et al. (2008). "Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells". Chembiochem. 9 (1): 77–92. doi:10.1002/cbic.200700358. PMID18072184. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Tawaramoto MS; Park SY; Tanaka Y; et al. (2003). "Crystal structure of the human centromere protein B (CENP-B) dimerization domain at 1.65-A resolution". J. Biol. Chem. 278 (51): 51454–61. doi:10.1074/jbc.M310388200. PMID14522975. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: unflagged free DOI (link)
Tanaka Y; Tachiwana H; Yoda K; et al. (2005). "Human centromere protein B induces translational positioning of nucleosomes on alpha-satellite sequences". J. Biol. Chem. 280 (50): 41609–18. doi:10.1074/jbc.M509666200. PMID16183641. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: unflagged free DOI (link)
Lim J; Hao T; Shaw C; et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID16713569. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Lomonte P, Morency E (2007). "Centromeric protein CENP-B proteasomal degradation induced by the viral protein ICP0". FEBS Lett. 581 (4): 658–62. doi:10.1016/j.febslet.2007.01.027. PMID17258208.
Suzuki N; Nakano M; Nozaki N; et al. (2004). "CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization". J. Biol. Chem. 279 (7): 5934–46. doi:10.1074/jbc.M306477200. PMID14612452. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)CS1 maint: unflagged free DOI (link)
Hellwig D; Münch S; Orthaus S; et al. (2008). "Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B". J Biophotonics. 1 (3): 245–54. doi:10.1002/jbio.200810014. PMID19412974. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Obuse C; Yang H; Nozaki N; et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID15009096. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Perdoni F; Bottone MG; Soldani C; Alpini, Claudia; Pellicciari, Carlo; Scovassi, Anna Ivana; et al. (2009). "Distribution of centromeric proteins and PARP-1 during mitosis and apoptosis". Ann. N. Y. Acad. Sci. 1171: 32–7. doi:10.1111/j.1749-6632.2009.04729.x. PMID19723035. {{cite journal}}: Missing |author4= (help); Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)