CENPI

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CENPI
Identifiers
AliasesCENPI, CENP-I, FSHPRH1, LRPR1, Mis6, centromere protein I
External IDsOMIM: 300065 MGI: 2147897 HomoloGene: 4899 GeneCards: CENPI
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for CENPI
Genomic location for CENPI
BandXq22.1Start101,098,218 bp[1]
End101,163,681 bp[1]
RNA expression pattern
PBB GE CENPI 214804 at fs.png

PBB GE CENPI 207590 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006733
NM_001318521
NM_001318523

NM_145924
NM_001305631

RefSeq (protein)

NP_001305450
NP_001305452
NP_006724

NP_001292560
NP_666036

Location (UCSC)Chr X: 101.1 – 101.16 MbChr X: 134.31 – 134.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centromere protein I is a protein that in humans is encoded by the CENPI gene.[5][6]

Function[edit]

The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis.[6] CENPI is a target gene of the transcription factor E2F.[7] Additionally, CENPI expression is increased in breast cancer and this has been shown to cause chromosome instability in breast cancer cells.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102384 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031262 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420.
  6. ^ a b "Entrez Gene: CENPI centromere protein I".
  7. ^ a b Thangavelu PU, Lin CY, Vaidyanathan S, Nguyen TH, Dray E, Duijf PH (September 2017). "CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer". Oncotarget. 8 (37): 62167–62182. doi:10.18632/oncotarget.19131. PMC 5617495. PMID 28977935.

Further reading[edit]

External links[edit]