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Protein TINF2 PDB 3BQO.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases TINF2, DKCA3, TIN2, TERF1 interacting nuclear factor 2
External IDs MGI: 107246 HomoloGene: 8264 GeneCards: 26277
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 14: 24.24 – 24.24 Mb Chr 14: 55.68 – 55.68 Mb
PubMed search [1] [2]
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TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene.[1][2] TIN2 is a component of the shelterin protein complex found at the end of telomeres.[3]


TINF2 has been shown to interact with ACD,[4][5] POT1[4][5][6] and TERF1.[1][5][7]


  1. ^ a b Kim SH, Kaminker P, Campisi J (Dec 1999). "TIN2, a new regulator of telomere length in human cells". Nature Genetics 23 (4): 405–12. doi:10.1038/70508. PMID 10581025. 
  2. ^ "Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2". 
  3. ^ Savage SA, Giri N, Baerlocher GM, Orr N, Lansdorp PM, Alter BP (Feb 2008). "TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita". American Journal of Human Genetics 82 (2): 501–9. doi:10.1016/j.ajhg.2007.10.004. PMC 2427222. PMID 18252230. 
  4. ^ a b Ye JZ, Hockemeyer D, Krutchinsky AN, Loayza D, Hooper SM, Chait BT, de Lange T (Jul 2004). "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex". Genes & Development 18 (14): 1649–54. doi:10.1101/gad.1215404. PMC 478187. PMID 15231715. 
  5. ^ a b c Liu D, Safari A, O'Connor MS, Chan DW, Laegeler A, Qin J, Songyang Z (Jul 2004). "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology 6 (7): 673–80. doi:10.1038/ncb1142. PMID 15181449. 
  6. ^ Loayza D, De Lange T (Jun 2003). "POT1 as a terminal transducer of TRF1 telomere length control". Nature 423 (6943): 1013–8. doi:10.1038/nature01688. PMID 12768206. 
  7. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 

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