Chlorobutanol
Appearance
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Names | |||
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IUPAC name
1,1,1-Trichloro-2-methylpropan-2-ol
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Other names
1,1,1-trichloro-2-methyl-2-propanol, chlorbutol, chloreton, chloretone, chlortran, trichloro-tert-butyl alcohol, 1,1,1-trichloro-tert-butyl alcohol, 2-(trichloromethyl)propan-2-ol, 1,1,1-trichloro-2-methyl-2-propanol, tert-Trichlorobutyl alcohol, trichloro-tert-butanol, trichlorisobutylalcohol, 2,2,2-trichloro-1,1-dimethylethanol
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Identifiers | |||
ECHA InfoCard | 100.000.288 | ||
CompTox Dashboard (EPA)
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Properties | |||
C4H7Cl3O | |||
Molar mass | 175.5 g/mol | ||
Appearance | White solid | ||
Melting point | 95 - 99°C | ||
Boiling point | 167°C | ||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chlorobutanol, or 1,1,1-trichloro-2-methyl-2-propanol, is a chemical preservative, sedative hypnotic and weak local anaesthetic similar in nature to chloral hydrate.
Chemical synthesis
Chlorobutanol is formed by the simple nucleophilic addition of chloroform and acetone. The reaction is base driven by potassium or sodium hydroxide. Recently, Jawwad & Kashif have prepared Chlorobutanol from chloroform and acetone under phase-transfer catalyzed conditions in high yields.