Co-tenidone

Co-tenidone

Combination of
Atenolol	Beta blocker
Chlortalidone	Thiazide diuretic
Clinical data
Routes of administration	Oral
Legal status
Legal status	UK: POM (Prescription only)
Identifiers
ChemSpider	151231 Y
Chemical and physical data
3D model (JSmol)	Interactive image
SMILES O=C(N)Cc1ccc(OCC(O)CNC(C)C)cc1.O=S(=O)(N)c1c(Cl)ccc(c1)C2(O)c3ccccc3C(=O)N2
InChI InChI=1S/C14H11ClN2O4S.C14H22N2O3/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14;1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h1-7,19H,(H,17,18)(H2,16,20,21);3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18) Y Key:GEGCOFDJWXJACT-UHFFFAOYSA-N Y
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Co-tenidone (BAN) is a non-proprietary name used to denote a combination of atenolol and chlortalidone. Co-tenidone is used in the treatment of hypertension. The use of β-blockers in hypertension was downgraded in June 2006 in the United Kingdom to fourth-line because they perform less well than other drugs, and because atenolol, the most frequently used β-blocker, at usual doses carries an unacceptable risk of provoking type 2 diabetes.

Formulation

Two strengths of co-tenidone are currently available in the UK:

• 50 mg atenolol and 12.5 mg chlortalidone, BAN of Co-tenidone 50/12.5
• 100 mg atenolol and 25 mg chlortalidone, BAN of Co-tenidone 100/25

References

• British National Formulary 54 September 2007