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Comedocarcinoma is one kind of breast cancer which is most commonly very early-stage[1][2] which demonstrates central necrosis.[3] It is usually a type of ductal carcinoma in situ. Comedo carcinomas are usually non-infiltrating and intraductal tumors. However, there have been accounts of comedocarcinoma which has then diversified into other cell types and developed into infiltrating (invasive) ductal carcinoma.[4] Recurrence and survival rates differ for invasive breast cancer which has originated as comedocarcinoma compared with other types of cancer cells.[5]

The duct will have characteristic necrotic tissue with calcification that feels cord-like. Squeezing the duct will yield inspissated material that is cheese-like and similar in consistency to toothpaste.

Comedocarcinoma has also been described as a histopathological type of Sebaceous carcinoma


 This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

  1. ^ Yale: Cardiothoracic Imaging - Comedocarcinoma of the right breast Archived August 3, 2008, at the Wayback Machine
  2. ^ Definition: comedocarcinoma from Online Medical Dictionary
  3. ^ Wellfire Interactive. "Pathology Thread".
  4. ^ Shahid Pervez; Hassan Khan (2007). "Infiltrating ductal carcinoma breast with central necrosis closely mimicking ductal carcinoma in situ (comedo type): a case series". J Med Case Reports. 1: 83. doi:10.1186/1752-1947-1-83. PMC 2014768. PMID 17825107.
  5. ^ Bonnier P, Body G, Bessenay F, Charpin C, Fétissof F, Beedassy B, Lejeune C, Piana L (1999). "Prognostic factors in ductal carcinoma in situ of the breast: results of a retrospective study of 575 cases". Eur J Obstet Gynecol Reprod Biol. 84 (1): 27–35. doi:10.1016/s0301-2115(99)00007-x. PMID 10413223.

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