DSE (gene)

DSE
Identifiers
Aliases	DSE, DSEP, DSEPI, EDSMC2, SART-2, SART2, DS-epi1, dermatan sulfate epimerase
External IDs	OMIM: 605942; MGI: 2443455; HomoloGene: 8354; GeneCards: DSE; OMA:DSE - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	116,444,861 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	34,083,711 bp
RNA expression pattern
	Top expressed in
	parietal pleura; ; Achilles tendon; ; germinal epithelium; ; cartilage tissue; ; pericardium; ; synovial joint; ; visceral pleura; ; synovial membrane; ; Epithelium of choroid plexus; ; right lung;
	Top expressed in
	hand; ; stroma of bone marrow; ; decidua; ; dermis; ; intercostal muscle; ; Gonadal ridge; ; lumbar spinal ganglion; ; abdominal wall; ; calvaria; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	isomerase activity; chondroitin-glucuronate 5-epimerase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; endoplasmic reticulum; membrane; nucleoplasm; cytosol;
Biological process	chondroitin sulfate biosynthetic process; heparan sulfate proteoglycan biosynthetic process; dermatan sulfate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	29940
	212898
	ENSG00000111817
	ENSMUSG00000039497
	Q9UL01
	Q8BLI4
NM_001080976; NM_001322937; NM_001322938; NM_001322939; NM_001322940;
	NM_001322941; NM_001322943; NM_001322944; NM_013352; NM_001374520; NM_001374521; NM_001374522
	NM_172508
NP_001074445; NP_001309866; NP_001309867; NP_001309868; NP_001309869;
	NP_001309870; NP_001309872; NP_001309873; NP_037484; NP_001361449; NP_001361450; NP_001361451
	NP_766096
	Wikidata
View/Edit Human	View/Edit Mouse

Dermatan-sulfate epimerase is an enzyme that in humans is encoded by the DSE gene.^[5]^[6]^[7]^[8]^[9]

The protein encoded by this gene is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is localized to the endoplasmic reticulum. Two transcript variants encoding the same protein have been found for this gene.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111817 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039497 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (Mar 2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer. 94 (6): 1636–41. doi:10.1002/cncr.10421. PMID 11920522.
^ Maccarana M, Olander B, Malmstrom J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmstrom A (Apr 2006). "Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2". J Biol Chem. 281 (17): 11560–8. doi:10.1074/jbc.M513373200. PMID 16505484.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ ^a ^b "Entrez Gene: DSE dermatan sulfate epimerase".
^ Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (March 2002). "Expression of tumor rejection antigens in colorectal carcinomas". Cancer. 94 (6): 1636–41. doi:10.1002/cncr.10421. PMID 11920522.
^ Maccarana M, Olander B, Malmström J, Tiedemann K, Aebersold R, Lindahl U, Li JP, Malmström A (April 2006). "Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2". J. Biol. Chem. 281 (17): 11560–8. doi:10.1074/jbc.M513373200. PMID 16505484.{{cite journal}}: CS1 maint: unflagged free DOI (link)

References

Further reading