Diclofenamide

Diclofenamide
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601233
ATC code	S01EC02 (WHO) ;
Pharmacokinetic data
Protein binding	55%
Identifiers
	IUPAC name 4,5-Dichlorobenzene-1,3-disulfonamide;
CAS Number	120-97-8 ;
PubChem CID	3038;
IUPHAR/BPS	6807;
DrugBank	DB01144 ;
ChemSpider	2930 ;
UNII	VVJ6673MHY;
KEGG	D00518 ;
ChEBI	CHEBI:101085 ;
ChEMBL	ChEMBL17 ;
CompTox Dashboard (EPA)	DTXSID1022922 ;
ECHA InfoCard	100.004.037
Chemical and physical data
Formula	C6H6Cl2N2O4S2
Molar mass	305.16 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1c(cc(cc1Cl)S(=O)(=O)N)S(=O)(=O)N;
	InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) ; Key:GJQPMPFPNINLKP-UHFFFAOYSA-N ;
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Diclofenamide (or dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class.

Uses

Diclofenamide is used to treat glaucoma^[1]^[2] and therapy-resistant epilepsy.^[3]

^ International Drug Names: Diclofenamide
^ Kanski, J. J. (1968). "Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors". The British journal of ophthalmology. 52 (8): 642–643. doi:10.1136/bjo.52.8.642. PMC 506660. PMID 5724852.
^ Rucquoy, M.; Sorel, L. (1978). "Diclofenamide in the treatment of therapy-resistant epilepsy". Acta neurologica Belgica. 78 (3): 174–182. PMID 352085.

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