FKBP1B

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FKBP1B
Protein FKBP1B PDB 1c9h.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FKBP1B, FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase, FK506 binding protein 1B
External IDs MGI: 1336205 HomoloGene: 68380 GeneCards: FKBP1B
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for FKBP1B
Genomic location for FKBP1B
Band No data available Start 24,049,701 bp[1]
End 24,063,681 bp[1]
RNA expression pattern
PBB GE FKBP1B 206857 s at fs.png

PBB GE FKBP1B 209931 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004116
NM_054033
NM_001322963
NM_001322964

NM_016863

RefSeq (protein)

NP_001309892
NP_001309893
NP_004107
NP_473374

NP_058559

Location (UCSC) Chr 2: 24.05 – 24.06 Mb Chr 2: 4.83 – 4.84 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase FKBP1B is an enzyme that in humans is encoded by the FKBP1B gene.[5][6]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus). It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119782 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020635 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Arakawa H, Nagase H, Hayashi N, Fujiwara T, Ogawa M, Shin S, Nakamura Y (Jun 1994). "Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts". Biochem Biophys Res Commun. 200 (2): 836–43. PMID 7513996. doi:10.1006/bbrc.1994.1527. 
  6. ^ a b "Entrez Gene: FKBP1B FK506 binding protein 1B, 12.6 kDa". 

Further reading[edit]