G-Unit member 50 Cent sings the chorus while Tony Yayo and G-Unit members Young Buck and Lloyd Banks rap on their own verses. The song tells the story of how the rappers are engaging in a relationship with the same woman, though she does not know they know, and how they know she does not love any of them because her obvious flirtatiousness and love for other rappers. Several other rappers and performers are mentioned in the song along with examples of what she does that proves she does not truly love any of her men, as evidenced by the chorus ("I know you don't love me, you ain't the same when Jay-Z's around / I know you don't love me / I know you don't love me, you scream and holla when Eminem's in town.).
The music video is shown in split-screen with each rapper having their own screen. Whoever is rapping gets the larger screen, and the other three are shown concurrently with other woman in three smaller screens below. The main woman in the video is almost always with the man who is rapping, except during the first part Young Buck's rap when the main woman is seen in a fifth screen on her way to see him. In the end, after meeting with all the men individually, the woman is trapped in an elevator and embarrassed by all men revealing their knowledge of her promiscuity.