|Anatomical terms of neuroanatomy|
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GABAergic neurons within the amygdala, known as intercalated (ITC) cells, receive a strong projection from the IL medial prefrontal cortex (mPFC) in primates. ITC cells are thought to play a role as the 'off switch' for the amygdala, inhibiting the amygdala's central nucleus output neurons and its basolateral nucleus neurons. Further, it has been shown that electrical stimulation of IL reduces conditioned fear and strengthens extinction memory[clarification needed], explaining cortical control over extinction processes,[clarification needed] one of the simplest forms of emotional regulation.
Amygdala ITC cells receive strong projection from the IL mPFC in rodents as well.
- "Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear." Learn. Mem., Vol. 13, No. 6. (1 November 2006), pp. 728-733. Ivan Vidal-Gonzalez, Benjamin Vidal-Gonzalez, Scott L Rauch, Gregory J Quirk.
- Chiba et al., 2001; Ghashghaei and Barbas, 2002.
- Quirk, G.J. & Mueller, D. (2007). Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology Reviews, 1-17.
- McDonald et al., 1996.