|Elevation||198 m (650 ft)|
|Time zone||PST (UTC+5)|
Isakhel is an important town located in the west of Mianwali District. It is named after (Tarna to Isa Khan), a Niazi chief. Until November 1901 Isa Khel was the tehsil headquarters of Bannu District - however after the North-West Frontier Province was created from Punjab province, Bannu District was included in the NWFP without the Isakhel Tehsil. Isakhel became part of the newly formed Mianwali District of the Punjab.
The town was founded about 1830 by Ahmad Khan, ancestor of the present Khans of Isa Khel, who were the acknowledged heads of the trans-Indus Niazai; and it takes its name from Isa Khan, a religious teacher and noble governor in Sher Shah Suri court. The municipality was created in 1875. The present Khans of Isakhel still reside there. The town's administrative power belongs to the Khan of Isakhel, Abdul Rehman Khan Niazi, alias Babli Khan. He is an ex Provincial Minister for Prisons and Adviser to chief Minister Punjab.
A large percentage of the population are pathans some of whom who speak saraeiki and some of whom speak pashto. 
In 1901, during British rule, when the tehsil became part of Mianwali, the population of the town was 7,630. The income and expenditure during the ten years ending 1902-3 averaged Rs. 4,400. In 1903-4 the income was Rs. 5,100, chiefly derived from octroi; and the expenditure was Rs. 4,600. During that time a small cattle market was held weekly. The town contained a dispensary and a municipal vernacular middle school.