Insulin regulated aminopeptidase
Template:PBB Leucyl/cystinyl aminopeptidase, also known as cystinyl aminopeptidase (CAP), insulin-regulated aminopeptidase (IRAP), human placental leucine aminopeptidase (PLAP), oxytocinase, and vasopressinase, is an enzyme of the aminopeptidase group that in humans is encoded by the LNPEP gene.[1][2]
Mutations in this gene have been associated to psoriasis risk.(doi:10.1038/jid.2013.317)
Interactions
Cystinyl aminopeptidase has been shown to interact with TNKS2.[3][4][5]
References
- ^ Rogi T, Tsujimoto M, Nakazato H, Mizutani S, Tomoda Y (February 1996). "Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family". J Biol Chem. 271 (1): 56–61. doi:10.1074/jbc.271.1.56. PMID 8550619.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ "Entrez Gene: LNPEP leucyl/cystinyl aminopeptidase".
- ^ Sbodio, Juan I; Chi Nai-Wen (August 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. 277 (35). United States: 31887–92. doi:10.1074/jbc.M203916200. ISSN 0021-9258. PMID 12080061.
{{cite journal}}: Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help)CS1 maint: unflagged free DOI (link) - ^ Chi, N W; Lodish H F (December 2000). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles". J. Biol. Chem. 275 (49). UNITED STATES: 38437–44. doi:10.1074/jbc.M007635200. ISSN 0021-9258. PMID 10988299.
{{cite journal}}: Cite has empty unknown parameters:|laydate=,|laysummary=, and|laysource=(help)CS1 maint: unflagged free DOI (link) - ^ Sbodio, Juan I; Lodish Harvey F; Chi Nai-Wen (February 2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. 361 (Pt 3). England: 451–9. doi:10.1042/0264-6021:3610451. ISSN 0264-6021. PMC 1222327. PMID 11802774.
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Further reading
External links
External links
- Cystinyl+aminopeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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