Linoleate 11-lipoxygenase

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linoleate 11-lipoxygenase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a linoleate 11-lipoxygenase (EC is an enzyme that catalyzes the chemical reaction

linoleate + O2 (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate

Thus, the two substrates of this enzyme are linoleate and O2, whereas its product is (9Z,12Z)-(11S)-11-hydroperoxyoctadeca-9,12-dienoate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is linoleate:oxygen 11S-oxidoreductase. This enzyme is also called linoleate dioxygenase, manganese lipoxygenase. This enzyme participates in linoleic acid metabolism.


  • Hamberg M, Su C, Oliw E (1998). "Manganese lipoxygenase. Discovery of a bis-allylic hydroperoxide as product and intermediate in a lipoxygenase reaction". J. Biol. Chem. 273 (21): 13080–8. doi:10.1074/jbc.273.21.13080. PMID 9582346. 
  • Oliw EH, Su C, Skogstrom T, Benthin G (1998). "Analysis of novel hydroperoxides and other metabolites of oleic, linoleic, and linolenic acids by liquid chromatography-mass spectrometry with ion trap MSn". Lipids. 33 (9): 843–52. doi:10.1007/s11745-998-0280-0. PMID 9778131. 
  • Su C, Oliw EH (1998). "Manganese lipoxygenase. Purification and characterization". J. Biol. Chem. 273 (21): 13072–9. doi:10.1074/jbc.273.21.13072. PMID 9582345.