Liver sinusoid

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Liver sinusoid
Sinusoid of a rat liver with fenestrated endothelial cells. Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm.
Hepatic structure2.svg
Basic liver structure
Latin vas sinusoideum
TH H3.
FMA 17543
Anatomical terminology

A liver sinusoid is a type of sinusoidal blood vessel (with fenestrated, discontinuous endothelium) that serves as a location for mixing of the oxygen-rich blood from the hepatic artery and the nutrient-rich blood from the portal vein.[1]

Hepatocytes are separated from the sinusoids by the space of Disse. Kupffer cells are located inside the sinusoids and can take up and destroy foreign material such as bacteria. Hepatic stellate cells are present in the space of Disse and are involved in scar formation in response to liver damage.


The sinusoidal endothelial cells are cultured for a variety of research purposes. The utility of these cells are of particular interest. One problem to overcome is the reversing of cellular differentiation that has made these cells highly specialized phenotypically in vitro.[2]

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  1. ^ SIU SOM Histology GI
  2. ^ Sellaro TL, Ravindra AK, Stolz DB, Badylak SF. (September 2007). "Maintenance of hepatic sinusoidal endothelial cell phenotype in vitro using organ-specific extracellular matrix scaffolds". Tissue Eng. 13 (9): 2301–2310. doi:10.1089/ten.2006.0437. Retrieved 28 April 2013. 

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