Marburg acute multiple sclerosis
Marburg multiple sclerosis, also known as malignant, acute, or fulminant multiple sclerosis, is considered one of the multiple sclerosis borderline diseases, which is a collection of diseases classified by some as MS variants and by others as different diseases. Other diseases in this group are Neuromyelitis optica (NMO), Balo concentric sclerosis, and Schilder's disease.[1]
It took its name from Otto Marburg. It can be diagnosed in vivo with an MRI scan.[2]
It is usually lethal, but it has been found to be responsive to Mitoxantrone[3] and Alemtuzumab,[4] and it has also been responsive to autologous stem cell transplantation.[5] Recently it has been shown that it presents an heterogeneous response to medication, as standard MS does.[6]
References
- ^ Fontaine B (2001). "Borderline forms of multiple sclerosis". Rev. Neurol. (Paris) (in French). 157 (8-9 Pt 2): 929–34. PMID 11787357.
- ^ In vivo MRI diagnosis
- ^ Responsiveness to Mitoxantrone
- ^ Alemtuzumab and craniotomy for severe acute demyelinating illness [1]
- ^ Kimiskidis VK, Sakellari I, Tsimourtou V; et al. (2007). "Autologous stem-cell transplantation in malignant multiple sclerosis: a case with a favorable long-term outcome". Multiple Sclerosis. 14: 278. doi:10.1177/1352458507082604. PMID 17942513.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ Leussink VI, Lehmann HC, Meyer Zu Hörste G, Hartung HP, Stüve O, Kieseier BC. (2008). "Rituximab induces clinical stabilization in a patient with fulminant multiple sclerosis not responding to natalizumab: Evidence for disease heterogeneity". Journal of Neurology. 255: 1436. doi:10.1007/s00415-008-0956-x. PMID 18685916.
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External links
- Marburg's Variant (Mult-sclerosis Encyclopedia)
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