N-acetylneuraminate 4-O-acetyltransferase

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N-acetylneuraminate 4-O-acetyltransferase
Identifiers
EC number2.3.1.44
CAS number51004-25-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a N-acetylneuraminate 4-O-acetyltransferase (EC 2.3.1.44) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + N-acetylneuraminate CoA + N-acetyl-4-O-acetylneuraminate

Thus, the two substrates of this enzyme are acetyl-CoA and N-acetylneuraminate, whereas its two products are CoA and N-acetyl-4-O-acetylneuraminate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase. This enzyme is also called sialate O-acetyltransferase.

References[edit]

  • Schauer R (May 1970). "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. I. Incorporation of (14C) acetate into sections of the submaxillary salivary gland of ox and horse]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 351 (5): 595–602. PMID 5446640.
  • Schauer R (June 1970). "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. II. Substrate and intracellular localization of bovine acetyl-coenzyme A: N-acetylneuraminate-7- and 8-O-acetyltransferase]". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. 351 (6): 749–58. doi:10.1515/bchm2.1970.351.1.749. PMID 5425947.