NADPH:quinone reductase

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NADPH:quinone reductase
EC number1.6.5.5
CAS number9032-20-6
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a NADPH:quinone reductase (EC is an enzyme that catalyzes the chemical reaction

NADPH + H+ + 2quinone NADP+ + 2semiquinone

The 3 substrates of this enzyme are NADPH, H+, and quinone, whereas its two products are NADP+ and semiquinone.

This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a quinone or similar compound as acceptor. The systematic name of this enzyme class is NADPH:quinone oxidoreductase. This enzyme is also called NADPH2:quinone reductase.

Structural studies[edit]

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1IYZ, 1IZ0, and 1YB5.


  • Rao PV, Krishna CM, Zigler JS Jr (1992). "Identification and characterization of the enzymatic activity of zeta-crystallin from guinea pig lens. A novel NADPH:quinone oxidoreductase". J. Biol. Chem. 267 (1): 96–102. PMID 1370456.