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Origin recognition complex, subunit 6
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ORC6 ; ORC6L
External IDs OMIM607213 MGI1929285 HomoloGene8635 GeneCards: ORC6 Gene
RNA expression pattern
PBB GE ORC6L 219105 x at tn.png
More reference expression data
Species Human Mouse
Entrez 23594 56452
Ensembl ENSG00000091651 ENSMUSG00000031697
UniProt Q9Y5N6 Q3TQX1
RefSeq (mRNA) NM_014321 NM_001163791
RefSeq (protein) NP_055136 NP_001157263
Location (UCSC) Chr 16:
46.69 – 46.7 Mb
Chr 8:
85.3 – 85.31 Mb
PubMed search [1] [2]
Origin recognition complex subunit 6 (ORC6)
Symbol ORC6
Pfam PF05460
InterPro IPR008721

Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.[1][2]


The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins.


The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and ORC1 are loosely associated with the core complex consisting of ORC2, -3, -4 and -5. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.[2]


ORC6 has been shown to interact with MCM5,[3] ORC2,[3][4] Replication protein A1,[3] ORC4,[3] DBF4,[3] ORC3,[3][4] CDC45-related protein,[3] MCM4[3] and Cell division cycle 7-related protein kinase.[3]


  1. ^ Dhar SK, Dutta A (Nov 2000). "Identification and characterization of the human ORC6 homolog". J Biol Chem 275 (45): 34983–8. doi:10.1074/jbc.M006069200. PMID 10945994. 
  2. ^ a b "Entrez Gene: ORC6L origin recognition complex, subunit 6 like (yeast)". 
  3. ^ a b c d e f g h i Kneissl, Margot; Pütter Vera; Szalay Aladar A; Grummt Friedrich (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. (England) 327 (1): 111–28. doi:10.1016/S0022-2836(03)00079-2. ISSN 0022-2836. PMID 12614612. 
  4. ^ a b Vashee, S; Simancek P; Challberg M D; Kelly T J (Jul 2001). "Assembly of the human origin recognition complex". J. Biol. Chem. (United States) 276 (28): 26666–73. doi:10.1074/jbc.M102493200. ISSN 0021-9258. PMID 11323433. 

Further reading[edit]