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Prenyl (decaprenyl) diphosphate synthase, subunit 2
Symbols PDSS2 ; C6orf210; COQ10D3; DLP1; bA59I9.3; hDLP1
External IDs OMIM610564 MGI1918615 HomoloGene56885 GeneCards: PDSS2 Gene
EC number
Species Human Mouse
Entrez 57107 71365
Ensembl ENSG00000164494 ENSMUSG00000038240
UniProt Q86YH6 Q33DR3
RefSeq (mRNA) NM_020381 NM_001168289
RefSeq (protein) NP_065114 NP_001161761
Location (UCSC) Chr 6:
107.15 – 107.46 Mb
Chr 10:
43.22 – 43.46 Mb
PubMed search [1] [2]

Decaprenyl-diphosphate synthase subunit 2 (PDSS2) is a protein that in humans is encoded by the PDSS2 gene.[1]


The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis.[1]

Clinical significance[edit]

It may be associated with Coenzyme Q10 deficiency.[2]

See also[edit]


Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.