PDSS2

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PDSS2
Identifiers
Aliases PDSS2, C6orf210, COQ10D3, DLP1, bA59I9.3, hDLP1, prenyl (decaprenyl) diphosphate synthase, subunit 2, decaprenyl diphosphate synthase subunit 2
External IDs MGI: 1918615 HomoloGene: 56885 GeneCards: PDSS2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020381

NM_001168289
NM_027772

RefSeq (protein)

NP_065114

NP_001161761.1
NP_082048.2
NP_001161761
NP_082048

Location (UCSC) Chr 6: 107.15 – 107.46 Mb Chr 10: 43.22 – 43.46 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Decaprenyl-diphosphate synthase subunit 2 (PDSS2) is a protein that in humans is encoded by the PDSS2 gene.[3]

Function[edit]

The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis.[3]

Clinical significance[edit]

It may be associated with Coenzyme Q10 deficiency.[4]

See also[edit]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.