Prolycopene isomerase

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Prolycopene isomerase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Prolycopene isomerase (EC, CRTISO, carotene cis-trans isomerase, ZEBRA2 (gene), carotene isomerase, carotenoid isomerase) is an enzyme with systematic name 7,9,7',9'-tetracis-lycopene cis-trans-isomerase.[1][2][3][4] This enzyme catalyses the following chemical reaction

7,9,7',9'-tetracis-lycopene all-trans-lycopene

This enzyme is involved in carotenoid biosynthesis.


  1. ^ Yu, Q.; Ghisla, S.; Hirschberg, J.; Mann, V.; Beyer, P. (2011). "Plant carotene cis-trans isomerase CRTISO: a new member of the FADred-dependent flavoproteins catalyzing non-redox reactions". J. Biol. Chem. 286: 8666–8676. PMC 3048748Freely accessible. PMID 21209101. doi:10.1074/jbc.m110.208017. 
  2. ^ Li, Q.; Farre, G.; Naqvi, S.; Breitenbach, J.; Sanahuja, G.; Bai, C.; Sandmann, G.; Capell, T.; Christou, P.; Zhu, C. (2010). "Cloning and functional characterization of the maize carotenoid isomerase and β-carotene hydroxylase genes and their regulation during endosperm maturation". Transgenic Res. 19: 1053–1068. PMID 20221689. doi:10.1007/s11248-010-9381-x. 
  3. ^ Isaacson, T.; Ronen, G.; Zamir, D.; Hirschberg, J. (2002). "Cloning of tangerine from tomato reveals a carotenoid isomerase essential for the production of β-carotene and xanthophylls in plants". Plant Cell. 14: 333–342. PMC 152916Freely accessible. PMID 11884678. doi:10.1105/tpc.010303. 
  4. ^ Chai, C.; Fang, J.; Liu, Y.; Tong, H.; Gong, Y.; Wang, Y.; Liu, M.; Wang, Y.; Qian, Q.; Cheng, Z.; Chu, C. (2011). "ZEBRA2, encoding a carotenoid isomerase, is involved in photoprotection in rice". Plant Mol. Biol. 75: 211–221. PMID 21161331. doi:10.1007/s11103-010-9719-z. 

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