RRM1

RRM1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WGH, 3HNC, 3HND, 3HNE, 3HNF, 5D1Y, 4X3V
Identifiers
Aliases	RRM1, R1, RIR1, RR1, ribonucleotide reductase catalytic subunit M1
External IDs	OMIM: 180410; MGI: 98180; HomoloGene: 806; GeneCards: RRM1; OMA:RRM1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	4,138,932 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	102,118,978 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; human penis; ; nipple; ; trabecular bone; ; skin of hip; ; skin of thigh; ; mucosa of pharynx; ; vulva; ; Achilles tendon;
	Top expressed in
	maxillary prominence; ; primitive streak; ; spermatocyte; ; dermis; ; abdominal wall; ; ureter; ; spermatid; ; somite; ; hair follicle; ; endocardial cushion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; catalytic activity; oxidoreductase activity; ATP binding; protein binding; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; identical protein binding; purine nucleotide binding; disordered domain specific binding;
Cellular component	cytoplasm; cytosol; nuclear envelope; ribonucleoside-diphosphate reductase complex; cell projection; neuronal cell body;
Biological process	DNA replication; metabolism; mitotic cell cycle; pyrimidine nucleobase metabolic process; male gonad development; deoxyribonucleotide biosynthetic process; response to ionizing radiation; cell proliferation in forebrain; protein complex oligomerization; protein heterotetramerization; retina development in camera-type eye; nucleobase-containing small molecule interconversion;
	Sources:Amigo / QuickGO
Orthologs
	6240
	20133
	ENSG00000167325
	ENSMUSG00000030978
	P23921
	P07742
	NM_001033; NM_001318064; NM_001318065; NM_001330193
	NM_009103
	NP_001024; NP_001304993; NP_001304994; NP_001317122
	NP_033129
	Wikidata
View/Edit Human	View/Edit Mouse

Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene.^[5]^[6]

Template:PBB Summary

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167325 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030978 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Parker NJ, Begley CG, Fox RM (Nov 1995). "Human gene for the large subunit of ribonucleotide reductase (RRM1): functional analysis of the promoter". Genomics. 27 (2): 280–5. doi:10.1006/geno.1995.1043. PMID 7557993.
^ "Entrez Gene: RRM1 ribonucleotide reductase M1 polypeptide".

v t e Other oxidoreductases (EC 1.15–1.21)
1.15: Acting on superoxide as acceptor	Superoxide dismutase SOD1 SOD2 SOD3
1.16: Oxidizing metal ions	Ceruloplasmin (Methionine synthase) reductase
1.17: Acting on CH or CH2 groups	Xanthine oxidase Ribonucleotide reductase 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase 7-Hydroxymethyl chlorophyll a reductase
1.18: Acting on iron–sulfur proteins as donors	Nitrogenase
1.19: Acting on reduced flavodoxin as donor	Nitrogenase (flavodoxin)
1.20: Acting on phosphorus or arsenic in donors	Glutaredoxin GLRX GLRX2 GLRX3 GLRX5
1.21: Acting on X-H and Y-H to form an X-Y bond	Isopenicillin N synthase Columbamine oxidase Reticuline oxidase Sulochrin oxidase (+)-bisdechlorogeodin-forming (-)-bisdechlorogeodin-forming Aureusidin synthase Tetrahydrocannabinolic acid synthase Cannabidiolic acid synthase Dichlorochromopyrrolate synthase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

RRM1

Interactive pathway map

See also

References

Further reading