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Sleeping sickness may refer to:
- African trypanosomiasis, also known as sleeping sickness, is a vector-borne parasitic disease. The parasites concerned are protozoa belonging to the Trypanosoma Genus. They are transmitted to humans by tsetse fly bites which have acquired their infection from human beings or from animals harbouring the human pathogenic parasites.
- Animal trypanosomiasis, also known as nagana or animal African trypanosomiasis
- Eastern equine encephalitis virus, a zoonotic alphavirus and arbovirus present in North, Central and South America and the Caribbean
- Encephalitis lethargica, a form of encephalitis that swept the world in the 1920s
- Fatigue (medical), any one of several other medical conditions that cause lethargy
- Sleeping Sickness (film), a 2011 German film
- "Sleeping Sickness" (song), a 2008 song by the band City and Colour
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