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Chloride channel, nucleotide-sensitive, 1A
Protein CLNS1A PDB 1zyi.png
PDB rendering based on 1zyi.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CLNS1A ; CLCI; CLNS1B; ICln
External IDs OMIM602158 MGI109638 HomoloGene990 GeneCards: CLNS1A Gene
RNA expression pattern
PBB GE CLNS1A 209143 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1207 12729
Ensembl ENSG00000074201 ENSMUSG00000025439
UniProt P54105 Q923F1
RefSeq (mRNA) NM_001293 NM_023671
RefSeq (protein) NP_001284 NP_076160
Location (UCSC) Chr 11:
77.51 – 77.64 Mb
Chr 7:
97.7 – 97.72 Mb
PubMed search [1] [2]

Methylosome subunit pICln is a protein that in humans is encoded by the CLNS1A gene.[1][2][3]


CLNS1A has been shown to interact with:

See also[edit]


  1. ^ Anguita J, Chalfant ML, Civan MM, Coca-Prados M (Apr 1995). "Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium". Biochem Biophys Res Commun 208 (1): 89–95. doi:10.1006/bbrc.1995.1309. PMID 7887970. 
  2. ^ Nagl UO, Erdel M, Schmarda A, Seri M, Pinggera GM, Gschwentner M, Duba C, Galietta LJ, Deetjen P, Utermann G, Paulmichl M (Mar 1997). "Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel ICln". Genomics 38 (3): 438–41. doi:10.1006/geno.1996.0651. PMID 8975725. 
  3. ^ "Entrez Gene: CLNS1A chloride channel, nucleotide-sensitive, 1A". 
  4. ^ Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. 279 (26): 27286–93. doi:10.1074/jbc.M402159200. PMID 15075326. 
  5. ^ a b c Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G (Dec 2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMC 99994. PMID 11713266. 
  6. ^ Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE (May 1998). "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology". J. Biol. Chem. 273 (18): 10811–4. doi:10.1074/jbc.273.18.10811. PMID 9556550. 
  7. ^ Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.