It has been settled since the early 19th century, first as a farming village. Later, the Delaware and Hudson Canal made it a key stop. Spring Glen is its third name. Originally established as Red Bank, it became Homowack (Iroquois for "where the stream begins" in 1851. Later in the century, the residents changed the name again, this time to Spring Glen, to attract more tourist business.
That tourism brought Jews to the region, and in 1917 they built Spring Glen Synagogue, the first Jewish place of worship in the Catskill region. The community became a small concentration of vacation bungalows, most of which are occupied only during the summer months. Recently these bungalows have been remodeled into permanent homes as the number of people coming from New York City to stay in the Catskills during the summer has declined.
Also one of the Ukrainian relics is located in Spring Glen at the Temple of Oriyana - a holy place for followers of the religion of RUNVira.