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tRNA (adenine-N1-)-methyltransferase

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tRNA (adenine-N1-)-methyltransferase
Identifiers
EC no.2.1.1.36
CAS no.37257-03-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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Gene OntologyAmiGO / QuickGO
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In enzymology, a tRNA (adenine-N1-)-methyltransferase (EC 2.1.1.36) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + tRNA S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine

Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing N1-methyladenine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase. Other names in common use include transfer ribonucleate adenine 1-methyltransferase, transfer RNA (adenine-1) methyltransferase, 1-methyladenine transfer RNA methyltransferase, adenine-1-methylase, and S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase.

References

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  • Baguley BC, Staehelin M (1968). "The specificity of transfer ribonucleic acid methylases from rat liver". Biochemistry. 7 (1): 45–50. doi:10.1021/bi00841a007. PMID 4921283.
  • Bjork GR, Svensson I (1969). "Studies on microbial RNA. Fractionation of tRNA methylases from Saccharomyces cerevisiae". Eur. J. Biochem. 9 (2): 207–15. doi:10.1111/j.1432-1033.1969.tb00596.x. PMID 4896260.
  • Dubois EG, Dirheimer G, Weil JH (1974). "Methylation of yeast tRNA Asp by enzymes from cytoplasm, chloroplasts and mitochondria of phaseolus vulgaris". Biochim. Biophys. Acta. 374 (3): 332–41. doi:10.1016/0005-2787(74)90254-8. PMID 4611497.
  • Glick JM, Leboy PS (1977). "Purification and properties of tRNA(adenine-1)-methyltransferase from rat liver". J. Biol. Chem. 252 (14): 4790–5. PMID 17605.