Talk:Dimercaptosuccinic acid

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Untitled[edit]

DMSA is water soluble. It does not cross the BBB. —The preceding unsigned comment was added by 149.164.12.85 (talkcontribs) .

Sorry, you'll have to provide a source for that. Wikipedia prefers verifiability over truth. —Keenan Pepper 18:11, 19 June 2006 (UTC)
I added two references of peer-reviewed journals stating that DMSA does not cross the BBB.--83.41.120.246 (talk) 07:59, 4 March 2008 (UTC)

Quick Comment[edit]

I have looked around the internet to find the following:

It states that the following holds : "A Closer Look at the Chelators

The most common chelators prescribed by the medical profession are EDTA, DMPS, and DMSA. These chelators are life-saving drugs in cases of acute metal poisoning. Of these, the DMSA and DMPS especially carry risks of harm, and should only be used as a last resort. "

Is this true? Does it not deserve mention on the wiki site in case someone tries something not necesarily so intelligent (such as to buy from the linked chemical suppliers page for their own personal mercury removal?). —temp_userbla 23:49, 29 November 2006 (UTC)

In the cited reference it is shown that DMSA crosses the BBB of mice, not of humans. Therefore the conclusion is, at least, disputed. I have changed the page accordingly. --Juliusllb 23:51, 11 February 2008 (UTC) —Preceding unsigned comment added by Juliusllb (talkcontribs)

NOTE: the CAS number listed is specific for the meso stereoisomer, whereas the name in the drugbox is unspecified as to stereoisomer —Preceding unsigned comment added by Reengler (talkcontribs) 17:21, 1 May 2008 (UTC)

Structure of complex[edit]

DMSA chelating an atom of mercury

The structure looks funny. Ionizable groups are still protonated, and I wonder if complex is a monomer. Is this structure really from a crystal structure? --Smokefoot (talk) 13:26, 16 August 2009 (UTC)

No I just made it up.
I'll have a look for something a little more evidence-based.
Ben (talk) 17:06, 16 August 2009 (UTC)

3D-structure is wrong[edit]

The 3D-structure shows the (2S,3S)-isomer not the meso-isomer as mentioned with the IUPAC name. Thus, the 3D-structure is wrong. Furthermore, the 2D-stucture is unclear, it may represent the meso-isomer as well as both enantiomers [(2S,3S)-isomer and (2R,3R)-isomer. Best regards, -- (talk) 12:07, 29 January 2011 (UTC)

If you look at the image description page for File:DMSA-3D-balls.png, you'll see that's it's based on Acta Cryst. C (1992) 48, 2007–2009, an experimental determination of the structure by x-ray crystallography. It is impossible that it is wrong. I have replaced the skeletal formula with a new one, File:Meso-2,3-dimercaptosuccinic-acid-2D-skeletal-A-configurations-labelled.png, showing the meso stereoisomer, which is the isomer actually used in medicine.
Ben (talk) 14:42, 29 January 2011 (UTC)

lead[edit]

i added a sentence to the lead explaining that the acid is often used to treat heavy metal toxicity. in my opinion, that is one of the more important aspects of the article, so i thought a comment on it belonged in the lead. let me know if you'd like to work on that section with me. thank you. GoGatorMeds (talk) 19:39, 27 June 2014 (UTC)