Nyakane attended school in Limpopo top rugby school Ben Vorster where he played for the first team for two years. He was chosen to represent Limpopo at the Grant Khomo, and Craven Weeks tournaments in 2006 and 2007
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Following his summer[when?] move from Toyota Cheetahs, Nyakane currently represents the Blue Bulls in both the Currie Cup and in Super Rugby. He has amassed more than 50 senior appearances in all senior competitions.
Nyakane signed a contract with the Blue Bulls until the end of the 2018 season.
He made his international debut on 8 June as a 73rd minute replacement for Tendai Mtawarira in South Africa's 44-10 victory over Italy in Durban. On 22 June 2013 he scored his first test try, against Samoa, in Pretoria. With South Africa already leading 49-23, Nyakane's 80th minute score completed a comprehensive victory.