The 2006 United States Senate election in Massachusetts was held November 7, 2006. Incumbent Democrat Ted Kennedy won re-election to his eighth full term. This was Kennedy's last election to the Senate; he died three years later of brain cancer, with which he was diagnosed in 2008. Senator Kennedy was the 4th longest-serving Senator in U.S. history, having been there for nearly 47 years.
At the Massachusetts Republican Party Convention Kenneth Chase received the official endorsement with a majority of delegates, though both candidates qualified for the September primary. Former White House Chief-of-Staff Andy Card also received 3 votes.
Kennedy captured every county in the state, winning at least 62% in each region. Kennedy served his ninth and final term until his death on August 25, 2009 (here, the completion of John Kennedy's unexpired term is considered to be Ted Kennedy's first term).