User:ProteinBoxBot/PBB Log Wiki 11-6-2007 B-5

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Log file for Protein Box Bot[edit]

Log page index: User:ProteinBoxBot/PBB_Log_Index

Protein Status Quick Log - Date: 08:11, 7 November 2007 (UTC)[edit]

Proteins without matches (16)[edit]

HMGA1 NQO1 CYBA EDNRB MAP2K4
HSF1 ID1 POLR2B EPHB2 KHDRBS1
NR5A1 GLA RELB HNRPA1 BID
MYH9

Proteins with a High Potential Match (9)[edit]

ARRB2 DAXX CAT CD86 PRL
GFAP MAPK9 SELL CIITA

Created (7)[edit]

HMGA1 MAP2K4 HSF1 POLR2B KHDRBS1
RELB HNRPA1

Manual Inspection (Page not found) (18)[edit]

ARRB2 DAXX NQO1 CYBA EDNRB
CAT ID1 CD86 PRL EPHB2
GFAP NR5A1 MAPK9 GLA SELL
CIITA BID MYH9


Protein Status Grid - Date: 08:11, 7 November 2007 (UTC)[edit]

HUGO Symbol Action Summary Target page(s) WP Symbol Search
ARRB2 Manual Inspection (Page not found) Other Pages: Arrestin (Protein Template); ARRB2 (No Data); ARB2 (No Data); Arb2 (No Data); ARR2 (No Data); Arr2 (No Data); DKFZp686L0365 (No Data); Dkfzp686l0365 (No Data); [1]
DAXX Manual Inspection (Page not found) Other Pages: Death-associated protein 6 (No Data); DAXX (Redirect -> Death associated protein 6); BING2 (No Data); Bing2 (No Data); DAP6 (No Data); Dap6 (No Data); MGC126245 (No Data); Mgc126245 (No Data); MGC126246 (No Data); Mgc126246 (No Data); Death associated protein 6 (Protein Template); [2]
HMGA1 Created Other Pages: High mobility group AT-hook 1 (No Data); HMGA1 (No Data); HMG-R (No Data); Hmg-r (No Data); HMGIY (No Data); Hmgiy (No Data); MGC12816 (No Data); Mgc12816 (No Data); MGC4242 (No Data); Mgc4242 (No Data); MGC4854 (No Data); Mgc4854 (No Data); [3]
NQO1 Manual Inspection (Page not found) Other Pages: NAD H dehydrogenase (No Data); NQO1 (No Data); DHQU (No Data); Dhqu (No Data); DIA4 (No Data); Dia4 (No Data); DTD (DisAmbig); Dtd (Redirect -> DTD); NMOR1 (No Data); Nmor1 (No Data); NMORI (No Data); Nmori (No Data); QR1 (No Data); Qr1 (No Data); [4]
CYBA Manual Inspection (Page not found) Other Pages: Cytochrome b-245 (No Data); CYBA (Redirect -> Banff Airport); Banff Airport (Unknown Data); [5]
EDNRB Manual Inspection (Page not found) Other Pages: Endothelin receptor type B (No Data); EDNRB (No Data); ABCDS (No Data); Abcds (No Data); ETB (DisAmbig); Etb (No Data); ETRB (No Data); Etrb (No Data); HSCR (No Data); Hscr (No Data); HSCR2 (No Data); Hscr2 (No Data); [6]
MAP2K4 Created Other Pages: Mitogen-activated protein kinase kinase 4 (No Data); MAP2K4 (No Data); JNKK (No Data); Jnkk (No Data); JNKK1 (No Data); Jnkk1 (No Data); MAPKK4 (No Data); Mapkk4 (No Data); MEK4 (No Data); Mek4 (No Data); MKK4 (No Data); Mkk4 (No Data); PRKMK4 (No Data); Prkmk4 (No Data); SEK1 (No Data); Sek1 (No Data); SERK1 (No Data); Serk1 (No Data); [7]
CAT Manual Inspection (Page not found) Other Pages: Catalase (Protein Template); CAT (Redirect -> Cat (disambiguation)); MGC138422 (No Data); Mgc138422 (No Data); MGC138424 (No Data); Mgc138424 (No Data); Cat (disambiguation) (DisAmbig); [8]
HSF1 Created Other Pages: Heat shock transcription factor 1 (No Data); HSF1 (No Data); HSTF1 (No Data); Hstf1 (No Data); [9]
ID1 Manual Inspection (Page not found) Other Pages: Inhibitor of DNA binding 1 (No Data); ID1 (No Data); ID (Unknown Data); Id (Redirect -> ID); [10]
CD86 Manual Inspection (Page not found) Other Pages: CD86 molecule (No Data); CD86 (Protein Template); B7-2 (No Data); B70 (DisAmbig); CD28LG2 (No Data); Cd28lg2 (No Data); LAB72 (No Data); Lab72 (No Data); MGC34413 (No Data); Mgc34413 (No Data); [11]
PRL Manual Inspection (Page not found) Other Pages: Prolactin (Protein Template); PRL (DisAmbig); [12]
POLR2B Created Other Pages: Polymerase polypeptide B (No Data); POLR2B (No Data); POL2RB (No Data); Pol2rb (No Data); RPB2 (No Data); Rpb2 (No Data); HRPB140 (No Data); Hrpb140 (No Data); HsRPB2 (No Data); Hsrpb2 (No Data); [13]
EPHB2 Manual Inspection (Page not found) Other Pages: EPH receptor B2 (No Data); EPHB2 (No Data); CAPB (Redirect -> Cocamidopropyl betaine); Capb (No Data); DRT (DisAmbig); Drt (No Data); EPHT3 (No Data); Epht3 (No Data); ERK (DisAmbig); Erk (Redirect -> Uzbekistan Liberty Democratic Party); Hek5 (No Data); MGC87492 (No Data); Mgc87492 (No Data); PCBC (DisAmbig); Pcbc (No Data); Tyro5 (No Data); Cocamidopropyl betaine (Unknown Data); Uzbekistan Liberty Democratic Party (Unknown Data); [14]
GFAP Manual Inspection (Page not found) Other Pages: Glial fibrillary acidic protein (Protein Template); GFAP (Redirect -> Glial_fibrillary_acidic_protein); FLJ45472 (No Data); Flj45472 (No Data); [15]
KHDRBS1 Created Other Pages: KH domain containing (No Data); KHDRBS1 (No Data); P62 (No Data); FLJ34027 (No Data); Flj34027 (No Data); Sam68 (No Data); [16]
NR5A1 Manual Inspection (Page not found) Other Pages: Nuclear receptor subfamily 5 (No Data); NR5A1 (No Data); AD4BP (No Data); Ad4bp (No Data); ELP (DisAmbig); Elp (Unknown Data); FTZ1 (No Data); Ftz1 (No Data); FTZF1 (No Data); Ftzf1 (No Data); SF-1 (No Data); Sf-1 (No Data); SF1 (Redirect -> SF 1); Sf1 (No Data); SF 1 (Unknown Data); [17]
MAPK9 Manual Inspection (Page not found) Other Pages: Mitogen-activated protein kinase 9 (Redirect -> C-Jun N-terminal kinases); MAPK9 (No Data); JNK-55 (No Data); Jnk-55 (No Data); JNK2 (No Data); Jnk2 (No Data); JNK2A (No Data); Jnk2a (No Data); JNK2ALPHA (No Data); Jnk2alpha (No Data); JNK2B (No Data); Jnk2b (No Data); JNK2BETA (No Data); Jnk2beta (No Data); PRKM9 (No Data); Prkm9 (No Data); P54aSAPK (No Data); P54asapk (No Data); C-Jun N-terminal kinases (Protein Template); [18]
GLA Manual Inspection (Page not found) Other Pages: Galactosidase (No Data); GLA (DisAmbig); GALA (Unknown Data); Gala (DisAmbig); [19]
SELL Manual Inspection (Page not found) Other Pages: Selectin L (No Data); SELL (No Data); CD62L (Redirect -> L-selectin); Cd62l (No Data); LAM-1 (No Data); Lam-1 (No Data); LAM1 (No Data); Lam1 (No Data); LECAM1 (No Data); Lecam1 (No Data); LNHR (No Data); Lnhr (No Data); LSEL (No Data); Lsel (No Data); LYAM1 (No Data); Lyam1 (No Data); Leu-8 (No Data); Lyam-1 (No Data); PLNHR (No Data); Plnhr (No Data); TQ1 (No Data); Tq1 (No Data); HLHRc (No Data); Hlhrc (No Data); L-selectin (Protein Template); [20]
CIITA Manual Inspection (Page not found) Other Pages: Class II (Redirect -> Appliance classes); CIITA (Protein Template); C2TA (No Data); C2ta (No Data); CIITA IV (No Data); Ciita iv (No Data); MHC2TA (No Data); Mhc2ta (No Data); NLRA (Redirect -> National Labor Relations Act); Nlra (No Data); Appliance classes (Unknown Data); National Labor Relations Act (Unknown Data); [21]
RELB Created Other Pages: V-rel reticuloendotheliosis viral oncogene homolog B (No Data); RELB (No Data); I-REL (No Data); I-rel (No Data); [22]
HNRPA1 Created Other Pages: Heterogeneous nuclear ribonucleoprotein A1 (No Data); HNRPA1 (No Data); HNRNPA1 (No Data); Hnrnpa1 (No Data); MGC102835 (No Data); Mgc102835 (No Data); [23]
BID Manual Inspection (Page not found) Other Pages: BH3 interacting domain death agonist (Unknown Data); BID (DisAmbig); MGC15319 (No Data); Mgc15319 (No Data); MGC42355 (No Data); Mgc42355 (No Data); [24]
MYH9 Manual Inspection (Page not found) Other Pages: Myosin (Unknown Data); MYH9 (No Data); DFNA17 (No Data); Dfna17 (No Data); EPSTS (No Data); Epsts (No Data); FTNS (No Data); Ftns (No Data); MGC104539 (No Data); Mgc104539 (No Data); MHA (DisAmbig); Mha (No Data); NMHC-II-A (No Data); Nmhc-ii-a (No Data); NMMHCA (No Data); Nmmhca (No Data); [25]

Vebose Log - Date: 08:11, 7 November 2007 (UTC)[edit]

ARRB2[edit]

  • INFO: Beginning work on ARRB2... {November 6, 2007 11:46:52 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:47:28 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Arrestin, beta 2
 | HGNCid = 712
 | Symbol = ARRB2
 | AltSymbols =; ARB2; ARR2; DKFZp686L0365
 | OMIM = 107941
 | ECnumber =  
 | Homologene = 3183
 | MGIid = 99474
 | GeneAtlas_image1 = PBB_GE_ARRB2_203388_at_tn.png
 | Function = 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} 
 | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007600 |text = sensory perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 409
    | Hs_Ensembl = ENSG00000141480
    | Hs_RefseqProtein = NP_004304
    | Hs_RefseqmRNA = NM_004313
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 4560533
    | Hs_GenLoc_end = 4571544
    | Hs_Uniprot = P32121
    | Mm_EntrezGene = 216869
    | Mm_Ensembl = ENSMUSG00000060216
    | Mm_RefseqmRNA = XM_993633
    | Mm_RefseqProtein = XP_998727
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 70248840
    | Mm_GenLoc_end = 70257023
    | Mm_Uniprot = Q3UCU5
  }}
}}
'''Arrestin, beta 2''', also known as '''ARRB2''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.<ref>{{cite web | title = Entrez Gene: ARRB2 arrestin, beta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=409| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Lefkowitz RJ |title=G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. |journal=J. Biol. Chem. |volume=273 |issue= 30 |pages= 18677-80 |year= 1998 |pmid= 9668034 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

BID[edit]

  • INFO: Beginning work on BID... {November 6, 2007 11:47:28 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein BID image.jpg {November 6, 2007 11:48:22 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:48:33 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_BID_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2bid.
 | PDB = {{PDB2|2bid}}
 | Name = BH3 interacting domain death agonist
 | HGNCid = 1050
 | Symbol = BID
 | AltSymbols =; MGC15319; MGC42355
 | OMIM = 601997
 | ECnumber =  
 | Homologene = 923
 | MGIid = 108093
 | GeneAtlas_image1 = PBB_GE_BID_204493_at_tn.png
 | GeneAtlas_image2 = PBB_GE_BID_211725_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0005123 |text = death receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005829 |text = cytosol}} 
 | Process = {{GNF_GO|id=GO:0001836 |text = release of cytochrome c from mitochondria}} {{GNF_GO|id=GO:0008625 |text = induction of apoptosis via death domain receptors}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 637
    | Hs_Ensembl = ENSG00000015475
    | Hs_RefseqProtein = NP_001187
    | Hs_RefseqmRNA = NM_001196
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 16596908
    | Hs_GenLoc_end = 16637431
    | Hs_Uniprot = P55957
    | Mm_EntrezGene = 12122
    | Mm_Ensembl = ENSMUSG00000004446
    | Mm_RefseqmRNA = NM_007544
    | Mm_RefseqProtein = NP_031570
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 120858471
    | Mm_GenLoc_end = 120882453
    | Mm_Uniprot = P70444
  }}
}}
'''BH3 interacting domain death agonist''', also known as '''BID''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.<ref>{{cite web | title = Entrez Gene: BID BH3 interacting domain death agonist| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=637| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Soane L, Fiskum G |title=Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins. |journal=J. Bioenerg. Biomembr. |volume=37 |issue= 3 |pages= 179-90 |year= 2006 |pmid= 16167175 |doi= 10.1007/s10863-005-6590-8 }}
}}
{{refend}}

{{protein-stub}}
 

CAT[edit]

  • INFO: Beginning work on CAT... {November 6, 2007 11:48:33 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein CAT image.jpg {November 6, 2007 11:49:21 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:49:34 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_CAT_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dgb.
 | PDB = {{PDB2|1dgb}}, {{PDB2|1dgf}}, {{PDB2|1dgg}}, {{PDB2|1dgh}}, {{PDB2|1f4j}}, {{PDB2|1qqw}}, {{PDB2|1tgu}}, {{PDB2|1th2}}, {{PDB2|1th3}}, {{PDB2|1th4}}, {{PDB2|4blc}}, {{PDB2|7cat}}, {{PDB2|8cat}}
 | Name = Catalase
 | HGNCid = 1516
 | Symbol = CAT
 | AltSymbols =; MGC138422; MGC138424
 | OMIM = 115500
 | ECnumber =  
 | Homologene = 55514
 | MGIid = 88271
 | GeneAtlas_image1 = PBB_GE_CAT_201432_at_tn.png
 | GeneAtlas_image2 = PBB_GE_CAT_211922_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0004096 |text = catalase activity}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005777 |text = peroxisome}} {{GNF_GO|id=GO:0005778 |text = peroxisomal membrane}} 
 | Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}} {{GNF_GO|id=GO:0042744 |text = hydrogen peroxide catabolic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 847
    | Hs_Ensembl = ENSG00000121691
    | Hs_RefseqProtein = NP_001743
    | Hs_RefseqmRNA = NM_001752
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 34417054
    | Hs_GenLoc_end = 34450176
    | Hs_Uniprot = P04040
    | Mm_EntrezGene = 12359
    | Mm_Ensembl = ENSMUSG00000027187
    | Mm_RefseqmRNA = NM_009804
    | Mm_RefseqProtein = NP_033934
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 103254746
    | Mm_GenLoc_end = 103285962
    | Mm_Uniprot = Q3TVZ1
  }}
}}
'''Catalase''', also known as '''CAT''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

CD86[edit]

  • INFO: Beginning work on CD86... {November 6, 2007 11:49:34 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein CD86 image.jpg {November 6, 2007 11:50:45 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:51:00 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_CD86_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1i85.
 | PDB = {{PDB2|1i85}}, {{PDB2|1ncn}}
 | Name = CD86 molecule
 | HGNCid = 1705
 | Symbol = CD86
 | AltSymbols =; B7-2; B70; CD28LG2; LAB72; MGC34413
 | OMIM = 601020
 | ECnumber =  
 | Homologene = 10443
 | MGIid = 101773
 | GeneAtlas_image1 = PBB_GE_CD86_205686_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_CD86_205685_at_tn.png
 | GeneAtlas_image3 = PBB_GE_CD86_210895_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015026 |text = coreceptor activity}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}} 
 | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} 
 | Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0042110 |text = T cell activation}} {{GNF_GO|id=GO:0043017 |text = positive regulation of lymphotoxin A biosynthetic process}} {{GNF_GO|id=GO:0045086 |text = positive regulation of interleukin-2 biosynthetic process}} {{GNF_GO|id=GO:0045404 |text = positive regulation of interleukin-4 biosynthetic process}} {{GNF_GO|id=GO:0045630 |text = positive regulation of T-helper 2 cell differentiation}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 942
    | Hs_Ensembl = ENSG00000114013
    | Hs_RefseqProtein = NP_008820
    | Hs_RefseqmRNA = NM_006889
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 123256911
    | Hs_GenLoc_end = 123322672
    | Hs_Uniprot = P42081
    | Mm_EntrezGene = 12524
    | Mm_Ensembl = ENSMUSG00000022901
    | Mm_RefseqmRNA = NM_019388
    | Mm_RefseqProtein = NP_062261
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 36523108
    | Mm_GenLoc_end = 36585290
    | Mm_Uniprot = Q3T9F8
  }}
}}
'''CD86 molecule''', also known as '''CD86''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.<ref>{{cite web | title = Entrez Gene: CD86 CD86 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=942| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Bugeon L, Dallman MJ |title=Costimulation of T cells. |journal=Am. J. Respir. Crit. Care Med. |volume=162 |issue= 4 Pt 2 |pages= S164-8 |year= 2000 |pmid= 11029388 |doi=  }}
*{{cite journal  | author=Chang TT, Kuchroo VK, Sharpe AH |title=Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. |journal=Curr. Dir. Autoimmun. |volume=5 |issue=  |pages= 113-30 |year= 2002 |pmid= 11826754 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

CIITA[edit]

  • INFO: Beginning work on CIITA... {November 7, 2007 12:01:44 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:02:39 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Class II, major histocompatibility complex, transactivator
 | HGNCid = 7067
 | Symbol = CIITA
 | AltSymbols =; C2TA; CIITA IV; MHC2TA; NLRA
 | OMIM = 600005
 | ECnumber =  
 | Homologene = 207
 | MGIid = 108445
 | GeneAtlas_image1 = PBB_GE_CIITA_211884_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_CIITA_210925_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}} {{GNF_GO|id=GO:0043130 |text = ubiquitin binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} 
 | Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4261
    | Hs_Ensembl = ENSG00000179583
    | Hs_RefseqProtein = NP_000237
    | Hs_RefseqmRNA = NM_000246
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 10867648
    | Hs_GenLoc_end = 10926340
    | Hs_Uniprot = P33076
    | Mm_EntrezGene = 12265
    | Mm_Ensembl = ENSMUSG00000022504
    | Mm_RefseqmRNA = NM_007575
    | Mm_RefseqProtein = NP_031601
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 10393637
    | Mm_GenLoc_end = 10441141
    | Mm_Uniprot = Q3UU40
  }}
}}
'''Class II, major histocompatibility complex, transactivator''', also known as '''CIITA''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the &quot;master control factor&quot; for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.<ref>{{cite web | title = Entrez Gene: CIITA class II, major histocompatibility complex, transactivator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4261| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Mach B, Steimle V, Martinez-Soria E, Reith W |title=Regulation of MHC class II genes: lessons from a disease. |journal=Annu. Rev. Immunol. |volume=14 |issue=  |pages= 301-31 |year= 1996 |pmid= 8717517 |doi= 10.1146/annurev.immunol.14.1.301 }}
*{{cite journal  | author=Boss JM |title=Regulation of transcription of MHC class II genes. |journal=Curr. Opin. Immunol. |volume=9 |issue= 1 |pages= 107-13 |year= 1997 |pmid= 9039770 |doi=  }}
*{{cite journal  | author=LeibundGut-Landmann S, Waldburger JM, Krawczyk M, ''et al.'' |title=Mini-review: Specificity and expression of CIITA, the master regulator of MHC class II genes. |journal=Eur. J. Immunol. |volume=34 |issue= 6 |pages= 1513-25 |year= 2004 |pmid= 15162420 |doi= 10.1002/eji.200424964 }}
*{{cite journal  | author=Ting JP, Davis BK |title=CATERPILLER: a novel gene family important in immunity, cell death, and diseases. |journal=Annu. Rev. Immunol. |volume=23 |issue=  |pages= 387-414 |year= 2005 |pmid= 15771576 |doi= 10.1146/annurev.immunol.23.021704.115616 }}
}}
{{refend}}

{{protein-stub}}
 

CYBA[edit]

  • INFO: Beginning work on CYBA... {November 6, 2007 11:51:00 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:51:27 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Cytochrome b-245, alpha polypeptide
 | HGNCid = 2577
 | Symbol = CYBA
 | AltSymbols =; 
 | OMIM = 608508
 | ECnumber =  
 | Homologene = 80
 | MGIid = 1316658
 | GeneAtlas_image1 = PBB_GE_CYBA_203028_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0009055 |text = electron carrier activity}} {{GNF_GO|id=GO:0020037 |text = heme binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0016020 |text = membrane}} 
 | Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006801 |text = superoxide metabolic process}} {{GNF_GO|id=GO:0006810 |text = transport}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1535
    | Hs_Ensembl = ENSG00000051523
    | Hs_RefseqProtein = NP_000092
    | Hs_RefseqmRNA = NM_000101
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 87237199
    | Hs_GenLoc_end = 87244958
    | Hs_Uniprot = P13498
    | Mm_EntrezGene = 13057
    | Mm_Ensembl = ENSMUSG00000006519
    | Mm_RefseqmRNA = NM_007806
    | Mm_RefseqProtein = NP_031832
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 125310866
    | Mm_GenLoc_end = 125319017
    | Mm_Uniprot = Q3TAM0
  }}
}}
'''Cytochrome b-245, alpha polypeptide''', also known as '''CYBA''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.<ref>{{cite web | title = Entrez Gene: CYBA cytochrome b-245, alpha polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1535| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Zalba G, San José G, Moreno MU, ''et al.'' |title=NADPH oxidase-mediated oxidative stress: genetic studies of the p22(phox) gene in hypertension. |journal=Antioxid. Redox Signal. |volume=7 |issue= 9-10 |pages= 1327-36 |year= 2006 |pmid= 16115038 |doi= 10.1089/ars.2005.7.1327 }}
}}
{{refend}}

{{protein-stub}}
 

DAXX[edit]

  • INFO: Beginning work on DAXX... {November 6, 2007 11:51:27 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:52:22 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Death-associated protein 6
 | HGNCid = 2681
 | Symbol = DAXX
 | AltSymbols =; BING2; DAP6; MGC126245; MGC126246
 | OMIM = 603186
 | ECnumber =  
 | Homologene = 1033
 | MGIid = 1197015
 | GeneAtlas_image1 = PBB_GE_DAXX_201763_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_DAXX_216038_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0019901 |text = protein kinase binding}} {{GNF_GO|id=GO:0031072 |text = heat shock protein binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0047485 |text = protein N-terminus binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016605 |text = PML body}} 
 | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007257 |text = activation of JNK activity}} {{GNF_GO|id=GO:0008625 |text = induction of apoptosis via death domain receptors}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1616
    | Hs_Ensembl = ENSG00000204209
    | Hs_RefseqProtein = NP_001341
    | Hs_RefseqmRNA = NM_001350
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 33394313
    | Hs_GenLoc_end = 33398769
    | Hs_Uniprot = Q9UER7
    | Mm_EntrezGene = 13163
    | Mm_Ensembl = ENSMUSG00000002307
    | Mm_RefseqmRNA = XM_993766
    | Mm_RefseqProtein = XP_998860
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 33519969
    | Mm_GenLoc_end = 33526038
    | Mm_Uniprot = A1A558
  }}
}}
'''Death-associated protein 6''', also known as '''DAXX''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

EDNRB[edit]

  • INFO: Beginning work on EDNRB... {November 6, 2007 11:53:45 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:54:59 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Endothelin receptor type B
 | HGNCid = 3180
 | Symbol = EDNRB
 | AltSymbols =; ABCDS; ETB; ETRB; HSCR; HSCR2
 | OMIM = 131244
 | ECnumber =  
 | Homologene = 89
 | MGIid = 102720
 | GeneAtlas_image1 = PBB_GE_EDNRB_204271_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_EDNRB_204273_at_tn.png
 | GeneAtlas_image3 = PBB_GE_EDNRB_206701_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0001600 |text = endothelin-B receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} 
 | Process = {{GNF_GO|id=GO:0001755 |text = neural crest cell migration}} {{GNF_GO|id=GO:0006885 |text = regulation of pH}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}} {{GNF_GO|id=GO:0007422 |text = peripheral nervous system development}} {{GNF_GO|id=GO:0007497 |text = posterior midgut development}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008217 |text = blood pressure regulation}} {{GNF_GO|id=GO:0030318 |text = melanocyte differentiation}} {{GNF_GO|id=GO:0048066 |text = pigmentation during development}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1910
    | Hs_Ensembl = ENSG00000136160
    | Hs_RefseqProtein = NP_000106
    | Hs_RefseqmRNA = NM_000115
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 77367617
    | Hs_GenLoc_end = 77391904
    | Hs_Uniprot = P24530
    | Mm_EntrezGene = 13618
    | Mm_Ensembl = ENSMUSG00000022122
    | Mm_RefseqmRNA = NM_007904
    | Mm_RefseqProtein = NP_031930
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 102700304
    | Mm_GenLoc_end = 102729852
    | Mm_Uniprot = Q8K1V9
  }}
}}
'''Endothelin receptor type B''', also known as '''EDNRB''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Endothelin receptor type B is a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene.  A splice variant, named SVR, has been described; the sequence of the ETB-SVR receptor is identical to ETRB except for the intracellular C-terminal domain.  While both splice variants bind ET1, they exhibit different responses upon binding which suggests that they may be functionally distinct.<ref>{{cite web | title = Entrez Gene: EDNRB endothelin receptor type B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1910| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Hofstra RM, Osinga J, Buys CH |title=Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype. |journal=Eur. J. Hum. Genet. |volume=5 |issue= 4 |pages= 180-5 |year= 1998 |pmid= 9359036 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

EPHB2[edit]

  • INFO: Beginning work on EPHB2... {November 6, 2007 11:54:59 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein EPHB2 image.jpg {November 6, 2007 11:56:27 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:56:53 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_EPHB2_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b4f.
 | PDB = {{PDB2|1b4f}}, {{PDB2|1f0m}}, {{PDB2|1jpa}}, {{PDB2|1kgy}}, {{PDB2|1nuk}}, {{PDB2|1sgg}}, {{PDB2|1shw}}, {{PDB2|2hen}}
 | Name = EPH receptor B2
 | HGNCid = 3393
 | Symbol = EPHB2
 | AltSymbols =; CAPB; DRT; EPHT3; ERK; Hek5; MGC87492; PCBC; Tyro5
 | OMIM = 600997
 | ECnumber =  
 | Homologene = 37925
 | MGIid = 99611
 | GeneAtlas_image1 = PBB_GE_EPHB2_209588_at_tn.png
 | GeneAtlas_image2 = PBB_GE_EPHB2_209589_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_EPHB2_210651_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005003 |text = ephrin receptor activity}} {{GNF_GO|id=GO:0005005 |text = transmembrane-ephrin receptor activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008046 |text = axon guidance receptor activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} 
 | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045202 |text = synapse}} 
 | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007612 |text = learning}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0048168 |text = regulation of neuronal synaptic plasticity}} {{GNF_GO|id=GO:0048170 |text = positive regulation of long-term neuronal synaptic plasticity}} {{GNF_GO|id=GO:0050770 |text = regulation of axonogenesis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2048
    | Hs_Ensembl = ENSG00000133216
    | Hs_RefseqProtein = NP_004433
    | Hs_RefseqmRNA = NM_004442
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 22910045
    | Hs_GenLoc_end = 23114405
    | Hs_Uniprot = P29323
    | Mm_EntrezGene = 13844
    | Mm_Ensembl = ENSMUSG00000028664
    | Mm_RefseqmRNA = NM_010142
    | Mm_RefseqProtein = NP_034272
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 135925688
    | Mm_GenLoc_end = 136108032
    | Mm_Uniprot = Q6GTQ7
  }}
}}
'''EPH receptor B2''', also known as '''EPHB2''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.<ref>{{cite web | title = Entrez Gene: EPHB2 EPH receptor B2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2048| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue=  |pages= 309-45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309 }}
*{{cite journal  | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151-81 |year= 1998 |pmid= 9576626 |doi=  }}
*{{cite journal  | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033-44 |year= 1999 |pmid= 10207129 |doi=  }}
*{{cite journal  | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue=  |pages= 177-244 |year= 2000 |pmid= 10730216 |doi=  }}
*{{cite journal  | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993-1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635 }}
*{{cite journal  | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155-64 |year= 2001 |pmid= 11256076 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

GFAP[edit]

  • INFO: Beginning work on GFAP... {November 6, 2007 11:57:50 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:58:30 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Glial fibrillary acidic protein
 | HGNCid = 4235
 | Symbol = GFAP
 | AltSymbols =; FLJ45472
 | OMIM = 137780
 | ECnumber =  
 | Homologene = 1554
 | MGIid = 95697
 | GeneAtlas_image1 = PBB_GE_GFAP_203540_at_tn.png
 | Function = {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005515 |text = protein binding}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005882 |text = intermediate filament}} 
 | Process = {{GNF_GO|id=GO:0045103 |text = intermediate filament-based process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2670
    | Hs_Ensembl = ENSG00000131095
    | Hs_RefseqProtein = NP_002046
    | Hs_RefseqmRNA = NM_002055
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 40338521
    | Hs_GenLoc_end = 40348388
    | Hs_Uniprot = P14136
    | Mm_EntrezGene = 14580
    | Mm_Ensembl = ENSMUSG00000020932
    | Mm_RefseqmRNA = NM_010277
    | Mm_RefseqProtein = NP_034407
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 102703437
    | Mm_GenLoc_end = 102713221
    | Mm_Uniprot = A0MTM0
  }}
}}
'''Glial fibrillary acidic protein''', also known as '''GFAP''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined.<ref>{{cite web | title = Entrez Gene: GFAP glial fibrillary acidic protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2670| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Garbuglia M, Verzini M, Sorci G, ''et al.'' |title=The calcium-modulated proteins, S100A1 and S100B, as potential regulators of the dynamics of type III intermediate filaments. |journal=Braz. J. Med. Biol. Res. |volume=32 |issue= 10 |pages= 1177-85 |year= 2000 |pmid= 10510252 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

GLA[edit]

  • INFO: Beginning work on GLA... {November 6, 2007 11:58:30 PM PST}
  • UPLOAD: Added new Image to wiki: PBB Protein GLA image.jpg {November 6, 2007 11:59:02 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:59:12 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_GLA_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1r46.
 | PDB = {{PDB2|1r46}}, {{PDB2|1r47}}
 | Name = Galactosidase, alpha
 | HGNCid = 4296
 | Symbol = GLA
 | AltSymbols =; GALA
 | OMIM = 301500
 | ECnumber =  
 | Homologene = 55441
 | MGIid = 1347344
 | GeneAtlas_image1 = PBB_GE_GLA_214430_at_tn.png
 | Function = {{GNF_GO|id=GO:0004553 |text = hydrolase activity, hydrolyzing O-glycosyl compounds}} {{GNF_GO|id=GO:0004557 |text = alpha-galactosidase activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0043169 |text = cation binding}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} 
 | Process = {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0009311 |text = oligosaccharide metabolic process}} {{GNF_GO|id=GO:0045019 |text = negative regulation of nitric oxide biosynthetic process}} {{GNF_GO|id=GO:0046479 |text = glycosphingolipid catabolic process}} {{GNF_GO|id=GO:0051001 |text = negative regulation of nitric-oxide synthase activity}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2717
    | Hs_Ensembl = ENSG00000102393
    | Hs_RefseqProtein = NP_000160
    | Hs_RefseqmRNA = NM_000169
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 100539453
    | Hs_GenLoc_end = 100549607
    | Hs_Uniprot = P06280
    | Mm_EntrezGene = 11605
    | Mm_Ensembl = ENSMUSG00000031266
    | Mm_RefseqmRNA = NM_013463
    | Mm_RefseqProtein = NP_038491
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 129934521
    | Mm_GenLoc_end = 129947287
    | Mm_Uniprot = Q3TLY5
  }}
}}
'''Galactosidase, alpha''', also known as '''GLA''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.<ref>{{cite web | title = Entrez Gene: GLA galactosidase, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2717| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Eng CM, Desnick RJ |title=Molecular basis of Fabry disease: mutations and polymorphisms in the human alpha-galactosidase A gene. |journal=Hum. Mutat. |volume=3 |issue= 2 |pages= 103-11 |year= 1994 |pmid= 7911050 |doi= 10.1002/humu.1380030204 }}
*{{cite journal  | author=Caillaud C, Poenaru L |title=[Gaucher's and Fabry's diseases: biochemical and genetic aspects] |journal=J. Soc. Biol. |volume=196 |issue= 2 |pages= 135-40 |year= 2002 |pmid= 12360742 |doi=  }}
*{{cite journal  | author=Germain DP |title=[Fabry's disease (alpha-galactosidase-A deficiency): physiopathology, clinical signs, and genetic aspects] |journal=J. Soc. Biol. |volume=196 |issue= 2 |pages= 161-73 |year= 2002 |pmid= 12360745 |doi=  }}
*{{cite journal  | author=Schaefer E, Mehta A, Gal A |title=Genotype and phenotype in Fabry disease: analysis of the Fabry Outcome Survey. |journal=Acta paediatrica (Oslo, Norway : 1992). Supplement |volume=94 |issue= 447 |pages= 87-92; discussion 79 |year= 2005 |pmid= 15895718 |doi=  }}
*{{cite journal  | author=Levin M |title=Fabry disease. |journal=Drugs Today |volume=42 |issue= 1 |pages= 65-70 |year= 2006 |pmid= 16511611 |doi= 10.1358/dot.2006.42.1.957357 }}
*{{cite journal  | author=Lidove O, Joly D, Barbey F, ''et al.'' |title=Clinical results of enzyme replacement therapy in Fabry disease: a comprehensive review of literature. |journal=Int. J. Clin. Pract. |volume=61 |issue= 2 |pages= 293-302 |year= 2007 |pmid= 17263716 |doi= 10.1111/j.1742-1241.2006.01237.x }}
}}
{{refend}}

{{protein-stub}}
 

HMGA1[edit]

  • INFO: Beginning work on HMGA1... {November 6, 2007 11:59:12 PM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 12:00:09 AM PST}
  • CREATED: Created new protein page: HMGA1 {November 7, 2007 12:00:16 AM PST}

HNRPA1[edit]

  • INFO: Beginning work on HNRPA1... {November 7, 2007 12:00:16 AM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein HNRPA1 image.jpg {November 7, 2007 12:00:30 AM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 12:00:42 AM PST}
  • CREATED: Created new protein page: HNRPA1 {November 7, 2007 12:00:50 AM PST}

HSF1[edit]

  • INFO: Beginning work on HSF1... {November 7, 2007 12:00:50 AM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 12:01:03 AM PST}
  • CREATED: Created new protein page: HSF1 {November 7, 2007 12:01:09 AM PST}

ID1[edit]

  • INFO: Beginning work on ID1... {November 7, 2007 12:01:10 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:01:44 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
 | HGNCid = 5360
 | Symbol = ID1
 | AltSymbols =; ID
 | OMIM = 600349
 | ECnumber =  
 | Homologene = 1631
 | MGIid = 96396
 | GeneAtlas_image1 = PBB_GE_ID1_208937_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} 
 | Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0030509 |text = BMP signaling pathway}} {{GNF_GO|id=GO:0043433 |text = negative regulation of transcription factor activity}} {{GNF_GO|id=GO:0045765 |text = regulation of angiogenesis}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3397
    | Hs_Ensembl = ENSG00000125968
    | Hs_RefseqProtein = NP_002156
    | Hs_RefseqmRNA = NM_002165
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 29656747
    | Hs_GenLoc_end = 29657979
    | Hs_Uniprot = P41134
    | Mm_EntrezGene = 15901
    | Mm_Ensembl = ENSMUSG00000042745
    | Mm_RefseqmRNA = NM_010495
    | Mm_RefseqProtein = NP_034625
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 152427715
    | Mm_GenLoc_end = 152428851
    | Mm_Uniprot = Q6GTZ3
  }}
}}
'''Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein''', also known as '''ID1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3397| accessdate = }}</ref>
}}

==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

KHDRBS1[edit]

  • INFO: Beginning work on KHDRBS1... {November 7, 2007 12:08:48 AM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 12:09:39 AM PST}
  • CREATED: Created new protein page: KHDRBS1 {November 7, 2007 12:09:46 AM PST}

MAP2K4[edit]

  • INFO: Beginning work on MAP2K4... {November 7, 2007 12:08:06 AM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 12:08:41 AM PST}
  • CREATED: Created new protein page: MAP2K4 {November 7, 2007 12:08:47 AM PST}

MAPK9[edit]

  • INFO: Beginning work on MAPK9... {November 7, 2007 12:04:07 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:05:13 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Mitogen-activated protein kinase 9
 | HGNCid = 6886
 | Symbol = MAPK9
 | AltSymbols =; JNK-55; JNK2; JNK2A; JNK2ALPHA; JNK2B; JNK2BETA; PRKM9; p54aSAPK
 | OMIM = 602896
 | ECnumber =  
 | Homologene = 55685
 | MGIid = 1346862
 | GeneAtlas_image1 = PBB_GE_MAPK9_203218_at_tn.png
 | GeneAtlas_image2 = PBB_GE_MAPK9_210570_x_at_tn.png
 | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004705 |text = JUN kinase activity}} {{GNF_GO|id=GO:0004707 |text = MAP kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} 
 | Component = 
 | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0007254 |text = JNK cascade}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5601
    | Hs_Ensembl = ENSG00000050748
    | Hs_RefseqProtein = NP_002743
    | Hs_RefseqmRNA = NM_002752
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 179595388
    | Hs_GenLoc_end = 179640218
    | Hs_Uniprot = P45984
    | Mm_EntrezGene = 26420
    | Mm_Ensembl = ENSMUSG00000020366
    | Mm_RefseqmRNA = NM_016961
    | Mm_RefseqProtein = NP_058657
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 49690177
    | Mm_GenLoc_end = 49729834
    | Mm_Uniprot = Q5NCK7
  }}
}}
'''Mitogen-activated protein kinase 9''', also known as '''MAPK9''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref>{{cite web | title = Entrez Gene: MAPK9 mitogen-activated protein kinase 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5601| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Davis RJ |title=Signal transduction by the JNK group of MAP kinases. |journal=Cell |volume=103 |issue= 2 |pages= 239-52 |year= 2000 |pmid= 11057897 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

MYH9[edit]

  • INFO: Beginning work on MYH9... {November 7, 2007 12:02:39 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:03:22 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Myosin, heavy chain 9, non-muscle
 | HGNCid = 7579
 | Symbol = MYH9
 | AltSymbols =; DFNA17; EPSTS; FTNS; MGC104539; MHA; NMHC-II-A; NMMHCA
 | OMIM = 160775
 | ECnumber =  
 | Homologene = 68257
 | MGIid = 107717
 | GeneAtlas_image1 = PBB_GE_MYH9_211926_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0000146 |text = microfilament motor activity}} {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003774 |text = motor activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0043495 |text = protein anchor}} {{GNF_GO|id=GO:0051015 |text = actin filament binding}} 
 | Component = {{GNF_GO|id=GO:0001725 |text = stress fiber}} {{GNF_GO|id=GO:0001726 |text = ruffle}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005826 |text = contractile ring}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005913 |text = cell-cell adherens junction}} {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016459 |text = myosin complex}} {{GNF_GO|id=GO:0032154 |text = cleavage furrow}} 
 | Process = {{GNF_GO|id=GO:0000904 |text = cellular morphogenesis during differentiation}} {{GNF_GO|id=GO:0000910 |text = cytokinesis}} {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0006509 |text = membrane protein ectodomain proteolysis}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0016337 |text = cell-cell adhesion}} {{GNF_GO|id=GO:0030048 |text = actin filament-based movement}} {{GNF_GO|id=GO:0030220 |text = platelet formation}} {{GNF_GO|id=GO:0030224 |text = monocyte differentiation}} {{GNF_GO|id=GO:0031532 |text = actin cytoskeleton reorganization}} {{GNF_GO|id=GO:0043534 |text = blood vessel endothelial cell migration}} {{GNF_GO|id=GO:0050900 |text = leukocyte migration}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4627
    | Hs_Ensembl = ENSG00000100345
    | Hs_RefseqProtein = NP_002464
    | Hs_RefseqmRNA = NM_002473
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 35007273
    | Hs_GenLoc_end = 35113958
    | Hs_Uniprot = P35579
    | Mm_EntrezGene = 17886
    | Mm_Ensembl = ENSMUSG00000022443
    | Mm_RefseqmRNA = NM_181327
    | Mm_RefseqProtein = NP_851844
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 77587843
    | Mm_GenLoc_end = 77669360
    | Mm_Uniprot = O89055
  }}
}}
'''Myosin, heavy chain 9, non-muscle''', also known as '''MYH9''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
}}
{{refend}}

{{protein-stub}}
 

NQO1[edit]

  • INFO: Beginning work on NQO1... {November 6, 2007 11:52:22 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein NQO1 image.jpg {November 6, 2007 11:53:26 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:53:45 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
| require_manual_inspection = no 
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_NQO1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d4a.
 | PDB = {{PDB2|1d4a}}, {{PDB2|1dxo}}, {{PDB2|1gg5}}, {{PDB2|1h66}}, {{PDB2|1h69}}, {{PDB2|1kbo}}, {{PDB2|1kbq}}, {{PDB2|1qbg}}, {{PDB2|2f1o}}
 | Name = NAD(P)H dehydrogenase, quinone 1
 | HGNCid = 2874
 | Symbol = NQO1
 | AltSymbols =; DHQU; DIA4; DTD; NMOR1; NMORI; QR1
 | OMIM = 125860
 | ECnumber =  
 | Homologene = 695
 | MGIid = 103187
 | GeneAtlas_image1 = PBB_GE_NQO1_201468_s_at_tn.png
 | GeneAtlas_image2 = PBB_GE_NQO1_201467_s_at_tn.png
 | GeneAtlas_image3 = PBB_GE_NQO1_210519_s_at_tn.png
 | Function = {{GNF_GO|id=GO:0003955 |text = NAD(P)H dehydrogenase (quinone) activity}} {{GNF_GO|id=GO:0004128 |text = cytochrome-b5 reductase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} 
 | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} 
 | Process = {{GNF_GO|id=GO:0006118 |text = electron transport}} {{GNF_GO|id=GO:0006805 |text = xenobiotic metabolic process}} {{GNF_GO|id=GO:0006809 |text = nitric oxide biosynthetic process}} {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}} {{GNF_GO|id=GO:0007271 |text = synaptic transmission, cholinergic}} {{GNF_GO|id=GO:0009636 |text = response to toxin}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1728
    | Hs_Ensembl = ENSG00000181019
    | Hs_RefseqProtein = NP_000894
    | Hs_RefseqmRNA = NM_000903
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 68300808
    | Hs_GenLoc_end = 68318034
    | Hs_Uniprot = P15559
    | Mm_EntrezGene = 18104
    | Mm_Ensembl = ENSMUSG00000003849
    | Mm_RefseqmRNA = NM_008706
    | Mm_RefseqProtein = NP_032732
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 110277948
    | Mm_GenLoc_end = 110282145
    | Mm_Uniprot = Q542Y0
  }}
}}
'''NAD(P)H dehydrogenase, quinone 1''', also known as '''NQO1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: NQO1 NAD(P)H dehydrogenase, quinone 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1728| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Vasiliou V, Ross D, Nebert DW |title=Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family. |journal=Hum. Genomics |volume=2 |issue= 5 |pages= 329-35 |year= 2006 |pmid= 16595077 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

NR5A1[edit]

  • INFO: Beginning work on NR5A1... {November 6, 2007 11:56:53 PM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein NR5A1 image.jpg {November 6, 2007 11:57:26 PM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 6, 2007 11:57:50 PM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_NR5A1_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ymt.
 | PDB = {{PDB2|1ymt}}, {{PDB2|1yow}}, {{PDB2|1yp0}}, {{PDB2|1zdt}}, {{PDB2|2a66}}, {{PDB2|2ff0}}
 | Name = Nuclear receptor subfamily 5, group A, member 1
 | HGNCid = 7983
 | Symbol = NR5A1
 | AltSymbols =; AD4BP; ELP; FTZ1; FTZF1; SF-1; SF1
 | OMIM = 184757
 | ECnumber =  
 | Homologene = 3638
 | MGIid = 1346833
 | GeneAtlas_image1 = PBB_GE_NR5A1_210333_at_tn.png
 | Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004879 |text = ligand-dependent nuclear receptor activity}} {{GNF_GO|id=GO:0005496 |text = steroid binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008289 |text = lipid binding}} {{GNF_GO|id=GO:0016439 |text = tRNA-pseudouridine synthase activity}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} 
 | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} 
 | Process = {{GNF_GO|id=GO:0001553 |text = luteinization}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007538 |text = primary sex determination}} {{GNF_GO|id=GO:0008406 |text = gonad development}} {{GNF_GO|id=GO:0008584 |text = male gonad development}} {{GNF_GO|id=GO:0009888 |text = tissue development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030325 |text = adrenal gland development}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0050810 |text = regulation of steroid biosynthetic process}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2516
    | Hs_Ensembl = ENSG00000136931
    | Hs_RefseqProtein = NP_004950
    | Hs_RefseqmRNA = NM_004959
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 126283337
    | Hs_GenLoc_end = 126309530
    | Hs_Uniprot = Q13285
    | Mm_EntrezGene = 26423
    | Mm_Ensembl = ENSMUSG00000026751
    | Mm_RefseqmRNA = NM_139051
    | Mm_RefseqProtein = NP_620639
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 38514636
    | Mm_GenLoc_end = 38536513
    | Mm_Uniprot = P97782
  }}
}}
'''Nuclear receptor subfamily 5, group A, member 1''', also known as '''NR5A1''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Morohashi KI, Omura T |title=Ad4BP/SF-1, a transcription factor essential for the transcription of steroidogenic cytochrome P450 genes and for the establishment of the reproductive function. |journal=FASEB J. |volume=10 |issue= 14 |pages= 1569-77 |year= 1997 |pmid= 9002548 |doi=  }}
*{{cite journal  | author=Parker KL, Schimmer BP |title=Steroidogenic factor 1: a key determinant of endocrine development and function. |journal=Endocr. Rev. |volume=18 |issue= 3 |pages= 361-77 |year= 1997 |pmid= 9183568 |doi=  }}
*{{cite journal  | author=Achermann JC, Meeks JJ, Jameson JL |title=Phenotypic spectrum of mutations in DAX-1 and SF-1. |journal=Mol. Cell. Endocrinol. |volume=185 |issue= 1-2 |pages= 17-25 |year= 2003 |pmid= 11738790 |doi=  }}
*{{cite journal  | author=Ozisik G, Achermann JC, Jameson JL |title=The role of SF1 in adrenal and reproductive function: insight from naturally occurring mutations in humans. |journal=Mol. Genet. Metab. |volume=76 |issue= 2 |pages= 85-91 |year= 2003 |pmid= 12083805 |doi=  }}
*{{cite journal  | author=Jameson JL |title=Of mice and men: The tale of steroidogenic factor-1. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 12 |pages= 5927-9 |year= 2005 |pmid= 15579738 |doi= 10.1210/jc.2004-2047 }}
*{{cite journal  | author=de-Souza BF, Lin L, Achermann JC |title=Steroidogenic factor-1 (SF-1) and its relevance to pediatric endocrinology. |journal=Pediatric endocrinology reviews : PER |volume=3 |issue= 4 |pages= 359-64 |year= 2006 |pmid= 16816804 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

POLR2B[edit]

  • INFO: Beginning work on POLR2B... {November 7, 2007 12:03:22 AM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 12:04:00 AM PST}
  • CREATED: Created new protein page: POLR2B {November 7, 2007 12:04:07 AM PST}

PRL[edit]

  • INFO: Beginning work on PRL... {November 7, 2007 12:05:13 AM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein PRL image.jpg {November 7, 2007 12:05:46 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:06:01 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image = PBB_Protein_PRL_image.jpg
 | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1n9d.
 | PDB = {{PDB2|1n9d}}, {{PDB2|1rw5}}
 | Name = Prolactin
 | HGNCid = 9445
 | Symbol = PRL
 | AltSymbols =; 
 | OMIM = 176760
 | ECnumber =  
 | Homologene = 732
 | MGIid = 97762
 | GeneAtlas_image1 = PBB_GE_PRL_205445_at_tn.png
 | Function = {{GNF_GO|id=GO:0005148 |text = prolactin receptor binding}} {{GNF_GO|id=GO:0005179 |text = hormone activity}} 
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} 
 | Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007516 |text = hemocyte development}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0007595 |text = lactation}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5617
    | Hs_Ensembl = ENSG00000172179
    | Hs_RefseqProtein = NP_000939
    | Hs_RefseqmRNA = NM_000948
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 22395459
    | Hs_GenLoc_end = 22405709
    | Hs_Uniprot = P01236
    | Mm_EntrezGene = 19109
    | Mm_Ensembl = ENSMUSG00000021342
    | Mm_RefseqmRNA = NM_011164
    | Mm_RefseqProtein = NP_035294
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 27065042
    | Mm_GenLoc_end = 27072657
    | Mm_Uniprot = Q3TT66
  }}
}}
'''Prolactin''', also known as '''PRL''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = 
}}

==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Bole-Feysot C, Goffin V, Edery M, ''et al.'' |title=Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. |journal=Endocr. Rev. |volume=19 |issue= 3 |pages= 225-68 |year= 1998 |pmid= 9626554 |doi=  }}
*{{cite journal  | author=Tansey MJ, Schlechte JA |title=Pituitary production of prolactin and prolactin-suppressing drugs. |journal=Lupus |volume=10 |issue= 10 |pages= 660-4 |year= 2002 |pmid= 11721691 |doi=  }}
*{{cite journal  | author=Montgomery DW |title=Prolactin production by immune cells. |journal=Lupus |volume=10 |issue= 10 |pages= 665-75 |year= 2002 |pmid= 11721692 |doi=  }}
*{{cite journal  | author=Stevens A, Ray DW, Worthington J, Davis JR |title=Polymorphisms of the human prolactin gene--implications for production of lymphocyte prolactin and systemic lupus erythematosus. |journal=Lupus |volume=10 |issue= 10 |pages= 676-83 |year= 2002 |pmid= 11721693 |doi=  }}
*{{cite journal  | author=Buckley AR |title=Prolactin, a lymphocyte growth and survival factor. |journal=Lupus |volume=10 |issue= 10 |pages= 684-90 |year= 2002 |pmid= 11721694 |doi=  }}
*{{cite journal  | author=Yu-Lee L |title=Stimulation of interferon regulatory factor-1 by prolactin. |journal=Lupus |volume=10 |issue= 10 |pages= 691-9 |year= 2002 |pmid= 11721695 |doi=  }}
*{{cite journal  | author=Welniak LA, Richards SM, Murphy WJ |title=Effects of prolactin on hematopoiesis. |journal=Lupus |volume=10 |issue= 10 |pages= 700-5 |year= 2002 |pmid= 11721696 |doi=  }}
*{{cite journal  | author=Hooghe R, Dogusan Z, Martens N, ''et al.'' |title=Effects of prolactin on signal transduction and gene expression: possible relevance for systemic lupus erythematosus. |journal=Lupus |volume=10 |issue= 10 |pages= 719-27 |year= 2002 |pmid= 11721698 |doi=  }}
*{{cite journal  | author=Matera L, Mori M, Galetto A |title=Effect of prolactin on the antigen presenting function of monocyte-derived dendritic cells. |journal=Lupus |volume=10 |issue= 10 |pages= 728-34 |year= 2002 |pmid= 11721699 |doi=  }}
*{{cite journal  | author=Jara LJ, Vera-Lastra O, Miranda JM, ''et al.'' |title=Prolactin in human systemic lupus erythematosus. |journal=Lupus |volume=10 |issue= 10 |pages= 748-56 |year= 2002 |pmid= 11721702 |doi=  }}
*{{cite journal  | author=Blanco-Favela F, Chavez-Rueda K, Leaños-Miranda A |title=Analysis of anti-prolactin autoantibodies in systemic lupus erythematosus. |journal=Lupus |volume=10 |issue= 10 |pages= 757-61 |year= 2002 |pmid= 11721703 |doi=  }}
*{{cite journal  | author=Méndez I, Cariño C, Díaz L |title=[Prolactin in the immunological system: synthesis and biological effects] |journal=Rev. Invest. Clin. |volume=57 |issue= 3 |pages= 447-56 |year= 2005 |pmid= 16187706 |doi=  }}
}}
{{refend}}

{{protein-stub}}
 

RELB[edit]

  • INFO: Beginning work on RELB... {November 7, 2007 12:06:01 AM PST}
  • UPLOAD: Added new Image to wiki: File:PBB Protein RELB image.jpg {November 7, 2007 12:06:37 AM PST}
  • CREATE: Found no pages, creating new page. {November 7, 2007 12:06:57 AM PST}
  • CREATED: Created new protein page: RELB {November 7, 2007 12:07:04 AM PST}

SELL[edit]

  • INFO: Beginning work on SELL... {November 7, 2007 12:07:04 AM PST}
  • AMBIGUITY: Did not locate an acceptable page to update. {November 7, 2007 12:08:06 AM PST}
 <!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes 
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
 | image =  
 | image_source =  
 | PDB = 
 | Name = Selectin L (lymphocyte adhesion molecule 1)
 | HGNCid = 10720
 | Symbol = SELL
 | AltSymbols =; CD62L; LAM-1; LAM1; LECAM1; LNHR; LSEL; LYAM1; Leu-8; Lyam-1; PLNHR; TQ1; hLHRc
 | OMIM = 153240
 | ECnumber =  
 | Homologene = 539
 | MGIid = 98279
 | GeneAtlas_image1 = PBB_GE_SELL_204563_at_tn.png
 | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}} 
 | Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} 
 | Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} 
 | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6402
    | Hs_Ensembl = ENSG00000188404
    | Hs_RefseqProtein = NP_000646
    | Hs_RefseqmRNA = NM_000655
    | Hs_GenLoc_db =  
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 167926432
    | Hs_GenLoc_end = 167947463
    | Hs_Uniprot = P14151
    | Mm_EntrezGene = 20343
    | Mm_Ensembl = ENSMUSG00000026581
    | Mm_RefseqmRNA = NM_011346
    | Mm_RefseqProtein = NP_035476
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 165899728
    | Mm_GenLoc_end = 165909011
    | Mm_Uniprot = Q3TA36
  }}
}}
'''Selectin L (lymphocyte adhesion molecule 1)''', also known as '''SELL''', is a human [[gene]].

<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title = 
| summary_text = SELL is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins.<ref>{{cite web | title = Entrez Gene: SELL selectin L (lymphocyte adhesion molecule 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6402| accessdate = }}</ref>
}}

==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading 
| citations = 
*{{cite journal  | author=Ryan US, Worthington RE |title=Cell-cell contact mechanisms. |journal=Curr. Opin. Immunol. |volume=4 |issue= 1 |pages= 33-7 |year= 1992 |pmid= 1375831 |doi=  }}
*{{cite journal  | author=Nicholson IC |title=CD62L (L-selectin). |journal=J. Biol. Regul. Homeost. Agents |volume=16 |issue= 2 |pages= 144-6 |year= 2003 |pmid= 12144128 |doi=  }}
*{{cite journal  | author=Ivetic A, Ridley AJ |title=The telling tail of L-selectin. |journal=Biochem. Soc. Trans. |volume=32 |issue= Pt 6 |pages= 1118-21 |year= 2005 |pmid= 15506984 |doi= 10.1042/BST0321118 }}
}}
{{refend}}

{{protein-stub}}
 

end log.