Esophagogastric junction outflow obstruction: Difference between revisions
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Rytyho usa (talk | contribs) add reference, reword, define IRP |
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==Signs and symptoms== |
==Signs and symptoms== |
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In some cases, EGJOO may cause no symptoms, and the manometry findings are identified during an evaluation prior to anti-reflux surgery. In other cases, EGJOO may be associated with chest pain or difficulty swallowing (dysphagia). |
In some cases, EGJOO may cause no symptoms, and the manometry findings are identified during an evaluation prior to anti-reflux surgery. In other cases, EGJOO may be associated with chest pain or difficulty swallowing (dysphagia). |
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==Diagnosis== |
==Diagnosis== |
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EGJOO is diagnosed using esophageal manometry.<ref name=Samo /> High resolution esophageal manometry will show elevated pressure at the LES with normal peristalsis.<ref name=Samo /> The LES pressure is evaluated immediately following a swallow, when the sphincter should relax.<ref name=Chicago2021 /> The overall LES pressure after a swallow is represented by the integrated relaxation pressure (IRP).<ref name=Chicago2021>{{cite journal |last1=Yadlapati |first1=R |last2=Kahrilas |first2=PJ |last3=Fox |first3=MR |last4=Bredenoord |first4=AJ |last5=Prakash Gyawali |first5=C |last6=Roman |first6=S |last7=Babaei |first7=A |last8=Mittal |first8=RK |last9=Rommel |first9=N |last10=Savarino |first10=E |last11=Sifrim |first11=D |last12=Smout |first12=A |last13=Vaezi |first13=MF |last14=Zerbib |first14=F |last15=Akiyama |first15=J |last16=Bhatia |first16=S |last17=Bor |first17=S |last18=Carlson |first18=DA |last19=Chen |first19=JW |last20=Cisternas |first20=D |last21=Cock |first21=C |last22=Coss-Adame |first22=E |last23=de Bortoli |first23=N |last24=Defilippi |first24=C |last25=Fass |first25=R |last26=Ghoshal |first26=UC |last27=Gonlachanvit |first27=S |last28=Hani |first28=A |last29=Hebbard |first29=GS |last30=Wook Jung |first30=K |last31=Katz |first31=P |last32=Katzka |first32=DA |last33=Khan |first33=A |last34=Kohn |first34=GP |last35=Lazarescu |first35=A |last36=Lengliner |first36=J |last37=Mittal |first37=SK |last38=Omari |first38=T |last39=Park |first39=MI |last40=Penagini |first40=R |last41=Pohl |first41=D |last42=Richter |first42=JE |last43=Serra |first43=J |last44=Sweis |first44=R |last45=Tack |first45=J |last46=Tatum |first46=RP |last47=Tutuian |first47=R |last48=Vela |first48=MF |last49=Wong |first49=RK |last50=Wu |first50=JC |last51=Xiao |first51=Y |last52=Pandolfino |first52=JE |title=Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0<sup>©</sup>. |journal=Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society |date=January 2021 |volume=33 |issue=1 |pages=e14058 |doi=10.1111/nmo.14058 |pmid=33373111}}</ref> If the IRP is abnormally elevated (>15 mmHg), this indicates an obstruction is present. Normal peristalsis with an obstruction at the esophagogastric junction (elevated IRP) is consistent with EGJOO.<ref name=Chicago2021 /> |
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EGJOO is diagnosed using esophageal manometry.<ref name=Samo /> High resolution esophageal manometry will show elevated pressure at the LES with normal peristalsis.<ref name=Samo /> The LES pressure is evaluated immediately following a swallowing, when the sphincter should relax. If the LES pressure remains elevated (>15 mmHg), this indicates obstruction is present. Normal peristalsis with an elevated IRP is consistent with EGJOO. |
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Upper endoscopy is used to evaluate for mechanical causes of obstruction.<ref name=Samo /> Endoscopic findings may include a hiatal hernia, esophagitis, strictures, tumors, or masses.<ref name=Samo /> Increased pressure at the LES over time may result in an epiphrenic diverticulum.<ref name=Samo /> Further evaluation for mechanical causes of obstruction may include CT scans, MRI, or endoscopic ultrasound.<ref name=Samo /> |
Upper endoscopy is used to evaluate for mechanical causes of obstruction.<ref name=Samo /> Endoscopic findings may include a hiatal hernia, esophagitis, strictures, tumors, or masses.<ref name=Samo /> Increased pressure at the LES over time may result in an epiphrenic diverticulum.<ref name=Samo /> Further evaluation for mechanical causes of obstruction may include CT scans, MRI, or endoscopic ultrasound.<ref name=Samo /> |
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Revision as of 05:27, 12 June 2021
| Esophagogastric junction outflow obstruction | |
|---|---|
| Other names | EGJOO |
| Specialty | Gastroenterology |
| Symptoms | Asymptomatic, dysphagia, chest pain |
| Types | Mechanical, anatomic, functional |
| Diagnostic method | High resolution manometry (esophageal manometry) |
| Differential diagnosis | Achalasia |
| Treatment | Pneumatic dilation, Per-oral endoscopic myotomy (POEM), botulinum toxin injection |
| Prognosis | Depends on etiology |
Esophagogastric junction outflow obstruction (EGJOO) is an esophageal motility disorder characterized by increased pressure where the esophagus connects to the stomach at the lower esophageal sphincter. EGJOO is diagnosed by esophageal manometry. However, EGJOO has a variety of etiologies; evaluating the cause of obstruction with additional testing, such as upper endoscopy, computed tomography (CT imaging), or endoscopic ultrasound may be necessary.[1] When possible, treatment of EGJOO should be directed at the cause of obstruction. When no cause for obstruction is found (functional EGJOO), observation alone may be considered if symptoms are minimal. Functional EGJOO with significant or refractor symptoms may be treated with pneumatic dilation, per-oral endoscopic myotomy (POEM), or botulinum toxin injection.
Signs and symptoms
In some cases, EGJOO may cause no symptoms, and the manometry findings are identified during an evaluation prior to anti-reflux surgery. In other cases, EGJOO may be associated with chest pain or difficulty swallowing (dysphagia).
Diagnosis
EGJOO is diagnosed using esophageal manometry.[1] High resolution esophageal manometry will show elevated pressure at the LES with normal peristalsis.[1] The LES pressure is evaluated immediately following a swallow, when the sphincter should relax.[2] The overall LES pressure after a swallow is represented by the integrated relaxation pressure (IRP).[2] If the IRP is abnormally elevated (>15 mmHg), this indicates an obstruction is present. Normal peristalsis with an obstruction at the esophagogastric junction (elevated IRP) is consistent with EGJOO.[2]
Upper endoscopy is used to evaluate for mechanical causes of obstruction.[1] Endoscopic findings may include a hiatal hernia, esophagitis, strictures, tumors, or masses.[1] Increased pressure at the LES over time may result in an epiphrenic diverticulum.[1] Further evaluation for mechanical causes of obstruction may include CT scans, MRI, or endoscopic ultrasound.[1]
Several additional tests may be used to further evaluate EGJOO.[1] Further evaluation of esophageal motor function may be accomplished with functional lumen imaging probe (FLIP).[1] Although not widely available, FLIP may help assess esophageal wall stiffness and compliance.[1] FLIP may help identify individuals with EGJOO who are likely to benefit from therapeutic procedures.[3]
Timed barium esophagram can help distinguish EGJOO from untreated achalasia.[1]
Treatment
Treatment primarily consists of addressing the underlying cause of EGJOO.[1] For example, gastroesophageal reflux disease (GERD) with reflux esophagitis is treated with proton pump inhibitors. Esophageal rings or strictures may be treated with esophageal dilation.
Simple observation may be considered,[4] especially if symptoms are minimal or absent. If symptoms are severe or persistent, peroral endoscopic myotomy (POEM) may be offered.[1]
Pneumatic dilation may be used for persistent symptoms in the absence of identified causes of mechanical obstruction.[1] Botulinum toxin may be considered,[4] especially for individuals who are unlikely to tolerate surgery.[1]
Etiology
Several causes for EGJOO exist.[1] Etiologies include early achalasia, mechanical processes (eosinophilic esophagitis, hiatal hernia, strictures, etc.), esophageal wall thickness (fibrosis, cancer, etc.), compression by nearby blood vessels (external vascular compression), obesity, opioid medication effect, or anatomic abnormalities.[1] The findings associated with EGJOO may be falsely abnormal due to measurement errors.[1]
Prognosis
The prognosis for EGJOO is generally favorable, in the absence of anatomic or mechanical causes, such as cancer. Individuals with minimal or no symptoms often experience resolution of the EGJOO, even without treatment.[1]
References
- ^ a b c d e f g h i j k l m n o p q r s Samo, S; Qayed, E (2019-01-28). "Esophagogastric junction outflow obstruction: Where are we now in diagnosis and management?". World journal of gastroenterology. 25 (4): 411–417. doi:10.3748/wjg.v25.i4.411. PMID 30700938.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ a b c Yadlapati, R; Kahrilas, PJ; Fox, MR; Bredenoord, AJ; Prakash Gyawali, C; Roman, S; Babaei, A; Mittal, RK; Rommel, N; Savarino, E; Sifrim, D; Smout, A; Vaezi, MF; Zerbib, F; Akiyama, J; Bhatia, S; Bor, S; Carlson, DA; Chen, JW; Cisternas, D; Cock, C; Coss-Adame, E; de Bortoli, N; Defilippi, C; Fass, R; Ghoshal, UC; Gonlachanvit, S; Hani, A; Hebbard, GS; Wook Jung, K; Katz, P; Katzka, DA; Khan, A; Kohn, GP; Lazarescu, A; Lengliner, J; Mittal, SK; Omari, T; Park, MI; Penagini, R; Pohl, D; Richter, JE; Serra, J; Sweis, R; Tack, J; Tatum, RP; Tutuian, R; Vela, MF; Wong, RK; Wu, JC; Xiao, Y; Pandolfino, JE (January 2021). "Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0©". Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 33 (1): e14058. doi:10.1111/nmo.14058. PMID 33373111.
- ^ Savarino, E; di Pietro, M; Bredenoord, AJ; Carlson, DA; Clarke, JO; Khan, A; Vela, MF; Yadlapati, R; Pohl, D; Pandolfino, JE; Roman, S; Gyawali, CP (November 2020). "Use of the Functional Lumen Imaging Probe in Clinical Esophagology". The American journal of gastroenterology. 115 (11): 1786–1796. doi:10.14309/ajg.0000000000000773. PMID 33156096.
- ^ a b Garbarino, S; von Isenburg, M; Fisher, DA; Leiman, DA (January 2020). "Management of Functional Esophagogastric Junction Outflow Obstruction: A Systematic Review". Journal of clinical gastroenterology. 54 (1): 35–42. doi:10.1097/MCG.0000000000001156. PMID 30575636.