1,3-Difluoro-2-propanol

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1,3-Difluoro-2-propanol
1,3-Difluoro-2-propanol.png
Identifiers
CAS number 453-13-4 N
PubChem 67985
ChemSpider 61300 YesY
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C3H6F2O
Molar mass 96.08 g mol−1
Density 1.24 g/cm3 (at 25 °C) [1]
Boiling point 54–55 °C
Hazards
Flash point 42 °C (108 °F; 315 K)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

1,3-Difluoro-2-propanol is a metabolic poison which disrupts the citric acid cycle and is used as a rodenticide, similar to sodium fluoroacetate. It is the main ingredient (along with 1-chloro-3-fluoro-2-propanol) in the rodenticide product Gliftor which was widely used in the former USSR.[2][3][4]

References[edit]

  1. ^ Sigma Aldrich
  2. ^ Buklan AI, Kravets AF (1986). "[Gliftor poisoning]". Sud. Med. Ekspert. (in Russian) 29 (1): 55–6. PMID 3961873. 
  3. ^ Feldwick MG, Noakes PS, Prause U, Mead RJ, Kostyniak PJ (1998). "The biochemical toxicology of 1,3-difluoro-2-propanol, the major ingredient of the pesticide gliftor: the potential of 4-methylpyrazole as an antidote". J. Biochem. Mol. Toxicol. 12 (1): 41–52. doi:10.1002/(SICI)1099-0461(1998)12:1<41::AID-JBT6>3.0.CO;2-P. PMID 9414486. 
  4. ^ Menon KI, Feldwick MG, Noakes PS, Mead RJ (2001). "The mode of toxic action of the pesticide gliftor: the metabolism of 1,3-difluoroacetone to (-)-erythro-fluorocitrate". J. Biochem. Mol. Toxicol. 15 (1): 47–54. doi:10.1002/1099-0461(2001)15:1<47::AID-JBT6>3.0.CO;2-E. PMID 11170315.