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sucrase-isomaltase (alpha-glucosidase)
Symbol SI
Entrez 6476
HUGO 10856
OMIM 609845
RefSeq NM_001041
UniProt P14410
Other data
EC number
Locus Chr. 3 q25.2-26.2

Sucrase-isomaltase (EC, oligo-1,6-glucosidase, limit dextrinase, isomaltase, exo-oligo-1,6-glucosidase, dextrin 6alpha-glucanohydrolase, alpha-limit dextrinase, dextrin 6-glucanohydrolase, oligosaccharide alpha-1,6-glucohydrolase) is a glucosidase enzyme with system name oligosaccharide 6-alpha-glucohydrolase.[1][2][3] This enzyme catalyses the following chemical reaction

Hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by enzyme EC

A deficiency is responsible for sucrose intolerance.

See also[edit]


  1. ^ Hauri, H.-P., Quaroni, A. and Isselbacher, K.J. (1979). "Biogenesis of intestinal plasma membrane: posttranslational route and cleavage of sucrase-isomaltase". Proc. Natl. Acad. Sci. USA 76: 5183–5186. doi:10.1073/pnas.76.10.5183. PMID 291933. 
  2. ^ Sjöström, H., Norén, O., Christiansen, L., Wacker, H. and Semenza, G. (1980). "A fully active, two-active-site, single-chain sucrase-isomaltase from pig small intestine. Implications for the biosynthesis of a mammalian integral stalked membrane protein". J. Biol. Chem. 255: 11332–11338. PMID 7002920. 
  3. ^ Rodriguez, I.R., Taravel, F.R. and Whelan, W.J. (1984). "Characterization and function of pig intestinal sucrase-isomaltase and its separate subunits". Eur. J. Biochem. 143: 575–582. doi:10.1111/j.1432-1033.1984.tb08408.x. PMID 6479163. 

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