Central Bethlehem Historic District is a national historic district located at Bethlehem, Lehigh County and Northampton County, Pennsylvania. The district includes 165 contributing buildings, 6 contributing sites (including Nisky Hill Cemetery), 9 contributing structures, and 4 contributing objects. It is primarily residential, but also includes commercial buildings along Main Street. Most of the buildings were built between the mid-18th to early-20th century. The buildings are primarily 2 1/2 stories tall and constructed of brick or stone. More recent residences are frame construction. The district encompasses building that reflect Bethlehem's development from a Moravian community, 1741-1844, to an industrial based economy, 1845-1938. Notable non-residential buildings include several communal Moravian buildings, the George H. Myers Building, and the Hill to Hill Bridge. Located in the district is the separately listed Lehigh Canal.