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Ethotoin structure.png
Systematic (IUPAC) name
Clinical data
AHFS/ Consumer Drug Information
MedlinePlus a682022
Pregnancy cat.
  • C
Legal status
Routes Oral
Pharmacokinetic data
Half-life 3 to 9 hours
CAS number 86-35-1 YesY
ATC code N03AB01
PubChem CID 3292
DrugBank DB00754
ChemSpider 3176 YesY
KEGG D00708 YesY
Chemical data
Formula C11H12N2O2 
Mol. mass 204.225 g/mol
 YesY (what is this?)  (verify)

Ethotoin (marketed as Peganone by Ovation) is an anticonvulsant drug used in the treatment of epilepsy. It is a hydantoin, similar to phenytoin. Ethotoin lacks phenytoin's side effects of gingival hyperplasia and hirsutism, however it is less effective. This, combined with the need for frequent dosing has limited its usefulness. Ethotoin is no longer widely used.

Mechanism of action[edit]

Similar to phenytoin.

Approval history[edit]

  • 1957 Peganone was granted Food and Drug Administration (FDA) approval to Abbott Laboratories for treatment of grand mal (tonic clonic) and partial complex (psychomotor) seizures.
  • 2003 Peganone was acquired from Abbott Laboratories by Ovation Pharmaceuticals (specialty pharmaceutical company who acquire underpromoted branded pharmaceutical products).

Indications and usage[edit]

Ethotoin is indicated for tonic-clonic and partial complex seizures.


Ethotoin is available in 250mg tablets. It is taken orally in 4 to 6 divided doses per day, preferably after food.

Side effects[edit]

Ataxia, visual disturbances, rash and gastrointestinal problems.


Ethotoin, 3-ethyl-5-phenylimidazolidine-2,4-dione, is synthesized by the reaction of benzaldehyde oxynitrile, with urea or ammonium hydrocarbonate, which forms an intermediate urea derivative which on acidic conditions cyclizes to 5-phenylhydantoin. Alkylation of this product using ethyliodide leads to the formation of ethotoin. Ethotoin synthesis.png


External links[edit]