|Classification and external resources|
Fitz-Hugh–Curtis syndrome is a rare complication of pelvic inflammatory disease (PID) named after the two physicians, Thomas Fitz-Hugh, Jr and Arthur Hale Curtis who first reported this condition in 1934 and 1930 respectively. It involves liver capsule inflammation.
Fitz-Hugh–Curtis syndrome occurs almost exclusively in women. It is usually caused by gonorrhoea (acute gonococcal perihepatitis) or chlamydia bacteria, which cause a thinning of cervical mucus and allow bacteria from the vagina into the uterus and oviducts, causing infection and inflammation. Occasionally, this inflammation can cause scar tissue to form on Glisson's capsule, a thin layer of connective tissue surrounding the liver.
Previously, Neisseria gonorrhoeae was thought to be the major organism responsible. Recent studies, however, have shown that cases of FHC due to infection with Chlamydia trachomatis outnumber those due to infection with Neisseria gonorrhoeae by a ratio of 5:1. Bacteroides spp., and facultative organisms such as Gardnerella, E. coli, and streptococcus may also play a role in some cases but are less commonly involved. 
Signs and Symptoms
The major symptom, following an episode of PID, is an acute onset, right upper quadrant (RUQ) abdominal pain aggravated by breathing, coughing or movement, which is referred to the right shoulder. Laparoscopy may reveal "violin string" adhesions of parietal peritoneum to liver.
Treatment involves diagnosing and treating the underlying cause correctly. The lysis of adhesions may be performed laparoscopically.
- synd/3324 at Who Named It?
- Fitz-Hugh Jr T. Acute gonococcic peritonitis of the right upper qrant in women. J Am Med Assoc 1934;102:2094-2096.
- Curtis AH. A cause of adhesion in the right upper qrant. JAMA 1930;94:1221-122.
- Peter, N. G.; Clark, L. R.; Jaeger, J. R. (2004). "Fitz-Hugh-Curtis syndrome: a diagnosis to consider in women with right upper quadrant pain". Cleveland Clinic journal of medicine 71 (3): 233–239. doi:10.3949/ccjm.71.3.233. PMID 15055246.