Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an enzyme that in humans is encoded by the GPX3gene.
GPx-3belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
^Takahashi K, Avissar N, Whitin J, Cohen H (August 1987). "Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme". Arch. Biochem. Biophys.256 (2): 677–86. doi:10.1016/0003-9861(87)90624-2. PMID3619451.
^Chu FF (1994). "The human glutathione peroxidase genes GPX2, GPX3, and GPX4 map to chromosomes 14, 5, and 19, respectively". Cytogenet. Cell Genet.66 (2): 96–8. doi:10.1159/000133675. PMID8287691.
Holtzman JL (2002). "The role of low levels of the serum glutathione-dependent peroxidase and glutathione and high levels of serum homocysteine in the development of cardiovascular disease.". Clin. Lab.48 (3-4): 129–30. PMID11934214.
Mistry HD, Kurlak LO, Williams PJ, et al. (2010). "Differential expression and distribution of placental glutathione peroxidases 1, 3 and 4 in normal and preeclamptic pregnancy.". Placenta31 (5): 401–8. doi:10.1016/j.placenta.2010.02.011. PMID20303587.
Iida R, Tsubota E, Yuasa I, et al. (2009). "Simultaneous genotyping of 11 non-synonymous SNPs in the 4 glutathione peroxidase genes using the multiplex single base extension method.". Clin. Chim. Acta402 (1-2): 79–82. doi:10.1016/j.cca.2008.12.027. PMID19161995.
Saga Y, Ohwada M, Suzuki M, et al. (2008). "Glutathione peroxidase 3 is a candidate mechanism of anticancer drug resistance of ovarian clear cell adenocarcinoma.". Oncol. Rep.20 (6): 1299–303. PMID19020706.
Zhang X, Yang JJ, Kim YS, et al. (2010). "An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer.". Int. J. Oncol.36 (2): 405–14. PMID20043075.
Wang Y, Fu W, Xie F, et al. (2010). "Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.". J. Hum. Genet.55 (8): 490–4. doi:10.1038/jhg.2010.53. PMID20485444.