Xylose isomerase
| xylose isomerase | |||||||
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| D-Xylose isomerase tetramer from Streptomyces rubiginosus PDB 2glk[1]. One monomer is coloured by secondray structure to highlight the TIM barrel architecture. | |||||||
| Identifiers | |||||||
| EC number | 5.3.1.5 | ||||||
| CAS number | 9023-82-9 | ||||||
| Databases | |||||||
| IntEnz | IntEnz view | ||||||
| BRENDA | BRENDA entry | ||||||
| ExPASy | NiceZyme view | ||||||
| KEGG | KEGG entry | ||||||
| MetaCyc | metabolic pathway | ||||||
| PRIAM | profile | ||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||
| Gene Ontology | AmiGO / EGO | ||||||
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In enzymology, a xylose isomerase (EC 5.3.1.5) is an enzyme that catalyzes the chemical reaction
This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is D-xylose aldose-ketose-isomerase. Other names in common use include D-xylose isomerase, D-xylose ketoisomerase, and D-xylose ketol-isomerase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism. The enzyme is used industrially to convert glucose to fructose in the manufacture of high-fructose corn syrup. It is sometimes referred to as "glucose isomerase".
[edit] Structural studies
Xylose isomerase enzymes exhibit a TIM barrel fold with the active site in the centre of the barrel and a tetrameric quaternary structure [2]. PDB structures are available in the links in the infobox to the right.
[edit] References
- ^ Katz, A. K.; Li, X.; Carrell, H. L.; Hanson, B. L.; Langan, P.; Coates, L.; Schoenborn, B. P.; Glusker, J. P. et al (2006). "Locating active-site hydrogen atoms in D-xylose isomerase: Time-of-flight neutron diffraction". Proceedings of the National Academy of Sciences 103 (22): 8342–8347. doi:10.1073/pnas.0602598103. PMC 1482496. PMID 16707576. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1482496.
- ^ http://www.ebi.ac.uk/pdbe-srv/PDBeXplore/enzyme/?ec=5.3.1.5&tab=assemblies
- HOCHSTER RM, WATSON RW (1954). "Enzymatic isomerization of D-xylose to D-xylulose". Arch. Biochem. Biophys. 48 (1): 120–9. doi:10.1016/0003-9861(54)90313-6. PMID 13125579.
- Slein MW (1955). "Xylose isomerase from Pasteurella pestis, strain A-1122". J. Am. Chem. Soc. 77 (6): 1663–1667. doi:10.1021/ja01611a074.
- Yamanaka K (1968). "Purification, crystallization and properties of the D-xylose isomerase from Lactobacillus brevis". Biochim. Biophys. Acta. 151 (3): 670–80. PMID 5646045.
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