Haemorrhagic disease of the newborn
| Haemorrhagic disease of the newborn | |
|---|---|
| Classification and external resources | |
 Vitamin K1 |
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| ICD-10 | P53 |
| ICD-9 | 776.0 |
| DiseasesDB | 29544 |
| MedlinePlus | 007320 |
| eMedicine | ped/966 |
| MeSH | D006475 |
Haemorrhagic disease of the newborn is a coagulation disturbance in newborns due to vitamin K deficiency. As a consequence of vitamin K deficiency there is an impaired production of coagulation factors II, VII, IX, X, C and S by the liver.
Contents |
Causes[edit]
Newborns are relatively vitamin K deficient for a variety of reasons. They have low vitamin K stores at birth, vitamin K passes the placenta poorly, the levels of vitamin K in breast milk are low and the gut flora has not yet been developed (vitamin K is normally produced by bacteria in the intestines).
Presentation[edit]
The disease causes an increased risk of bleeding. The most common sites of bleeding are the umbilicus, mucous membranes, gastrointestinal tract, circumcision and venipunctures.
Treatment[edit]
Treatment consists of vitamin K supplementation.[1] This is often given prophylactically to newborns shortly after birth.
References[edit]
- ^ Hubbard D, Tobias JD (November 2006). "Intracerebral hemorrhage due to hemorrhagic disease of the newborn and failure to administer vitamin K at birth". South. Med. J. 99 (11): 1216–20. PMID 17195415.
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